Comparison of self-reported and database-linked family history of cancer data in a case-control study.
Comparison of self-reported and database-linked family history of cancer data in a case-control study.
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DOI：
10.1093/oxfordjournals.aje.a009259
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发表时间：
1997-08
影响因子：
5
通讯作者：
Richard A. Kerber;Martha L. Slattery
中科院分区：
文献类型：
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作者：
Richard A. Kerber;Martha L. Slattery
作者将犹他州结肠癌饮食、活动和生殖研究（DARCC）研究（1992-1995）参与者的访谈数据与犹他州人口数据库（UPDB）中包含的家谱和癌症信息联系起来。他们评估了受试者报告家族性癌症的敏感性，并测量了报告和数据库记录与kappa统计数据之间的总体一致性。他们从逻辑回归中计算了比值比，以比较使用任何一组数据集（或两组数据集）所产生的相对风险估计。总体而言，犹他州DARCC受试者中有37.6%（881人中有331人）与UPDB家谱相关。对乳腺癌（83%）、结直肠癌（73%）和前列腺癌（70%）报告的高敏感性被观察到，而卵巢癌（60%）和子宫癌（30%）也没有报告。kappa的结果相似，乳腺癌的值为0.63，结直肠癌的值为0.56。虽然观察到的卵巢癌和子宫癌的kappa分别为0.36和0.25，超出了机会预期，但受试者报告和数据库记录之间的一致性并不令人印象深刻。在自我报告的准确性方面，观察到病例和对照组之间没有一致的差异。总体而言，年轻受试者的敏感性高于年长受试者；女性报告的癌症家族史仅略好于男性。大学教育程度并不总是与更准确地报告癌症家族史有关。这些结果表明，在病例对照研究中，受试者能够准确地报告几种常见癌症的家族史，而且他们这样做没有明显的回忆偏差。对于生殖道癌症和直肠癌等经常与类似器官的癌症混淆的癌症，自我报告的准确性可能不够。
The authors linked interview data drawn from Utah participants in the Diet, Activity, and Reproduction in Colon Cancer (DARCC) Study (1992-1995) to genealogic and cancer information contained in the Utah Population Database (UPDB). They evaluated the sensitivity of subjects' reports of familial cancers and measured the overall agreement between reported and database records with the kappa (kappa) statistic. They calculated odds ratios from logistic regression to compare the relative risk estimates that would result from use of either data set (or both data sets). Overall, 37.6% (331 of 881) of the Utah DARCC subjects were linked to the UPDB genealogy. High sensitivities were observed for subjects' reports of breast (83%), colorectal (73%), and prostate (70%) cancers, while ovarian (60%) and uterine (30%) cancers were not reported as well. Results for kappa were similar, with values of 0.63 for breast cancer and 0.56 for colorectal cancer. Although the observed kappa s of 0.36 and 0.25 for ovarian and uterine cancers, respectively, exceeded chance expectations, the agreement between subjects' reports and database records was unimpressive. No consistent difference was observed between cases and controls in the accuracy of self-reports. In general, higher sensitivities were observed among younger subjects than older subjects; females reported family histories of cancer only slightly better than males. A college education was not consistently associated with more accurate reporting of family history of cancer. These results indicate that subjects in a case-control study are able to report accurately family histories of several common kinds of cancer and that they can do so without observable recall bias. The accuracy of self-reports may not be adequate for reproductive tract cancers and cancers such as rectal cancer that are frequently confused with cancers of similar organs.