A DISTINCT HOX CODE FOR THE BRANCHIAL REGION OF THE VERTEBRATE HEAD
A DISTINCT HOX CODE FOR THE BRANCHIAL REGION OF THE VERTEBRATE HEAD
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DOI：
10.1038/353861a0
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发表时间：
1991-10-31
期刊：
影响因子：
64.8
通讯作者：
KRUMLAUF, R
中科院分区：
文献类型：
--
作者：
HUNT, P;GULISANO, M;KRUMLAUF, R
脊椎动物头部的颧区是通过菱形节段、神经脊和鳃弓的复杂相互作用形成的。人们认为，它们的模式形成机制的某些方面与2相连，涉及Hox-2基因，其重叠的和空间受限的表达结构域代表了产生区域多样性3-5的组合密码。脊椎动物拥有四个HOX簇的触角体类同源框基因，通过复制和偏离共同的祖先复合体3，6-8而相互关联。因此，在不同簇的相同位置上有高度相关的基因，称为亚家族或同源群体。由于Hox-2基因不能完全解释单个菱形单体的模式，我们调查了平行基因表达限制的偏移是否可以解释区域多样性的产生。我们在这里报道，除了唇亚家族外，同源基因在菱形核、头神经节和鳃弓中显示出相同的表达限制，为鳃区域提供了一个似乎在组织上与躯干不同的组合HOX编码。
THE branchial region of the vertebrate head forms through complex interactions involving rhombomeric segments, neural crest and branchial arches 1. It is thought that aspects of their patterning mechanisms are linked 2 and involve Hox-2 genes, whose overlapping and spatially restricted expression domains represent a combinatorial code for generating regional diversity 3-5. Vertebrates possess four Hox clusters of Antennapedia class homeobox genes, related to each other by duplication and divergence from a common ancestral complex 3,6-8. In consequence, at equivalent positions in different clusters there are highly related genes known as subfamilies or paralogous groups. As Hox-2 genes cannot fully account for patterning individual rhombomeres, we investigated whether offsets in expression limits of paralogous genes could account for the generation of regional diversity. We report here that, with the exception of the labial subfamily, paralogues show identical expression limits in rhombomeres, cranial ganglia and branchial arches, providing a combinatorial Hox code for the branchial region that seems to be different in organization to that of the trunk.