Itinerant Dynamics of Class I* Neurons Coupled by Gap Junctions
Itinerant Dynamics of Class I* Neurons Coupled by Gap Junctions
复制标题
DOI：
10.1007/978-3-540-27862-7_8
复制
发表时间：
2003-10
期刊：
影响因子：
--
通讯作者：
H. Fujii;I. Tsuda
中科院分区：
文献类型：
--
作者：
H. Fujii;I. Tsuda
尽管人们普遍认为“中间神经元在新皮层中产生各种同步的抑制节律..”(J. R. Gibsonet al.），它们“可能在协调皮质活动中起关键作用......”（M.加拉雷塔角Hestrin），很少有人知道它们在体内大脑皮层中的行为。新皮层中的一些中间神经元系统的一个显著特性是它们通过间隙连接（GJ）耦合-一种在相同类型的中间神经元之间非常强烈的电耦合。在我们以前的研究中，我们报道了理论上的可能性，一类神经元系统可能会表现出时空混沌时，他们耦合的GJ，而单个神经元，当孤立的，只表现出简单的重复放电。这种动力学是涌现的，只有当细胞通过GJ耦合时才会显露出来。从数学上讲，这种现象可能是伪吸引子（或吸引子废墟）之间混沌巡游的表现。鉴于GJ的普遍存在--在大脑皮层的六层中至少有五个不同的由GJ耦合的中间神经元系统，以及混沌巡回概念在记忆动力学中的重要意义，本文对GJ耦合神经元系统的一般性质和集体动力学进行了综述。
Although it is generally recognized that “interneurons generate a variety of synchronous inhibitory rhythms in the neocortex...”(J. R. Gibsonet al. ) and they “may play a key role in coordinating cortical activity...”(M. Galarreta & S. Hestrin), little is known how they behave in thein vivoneocortex. A salient property of some interneuron systems in the neocortex is that they are coupled by gap junctions (GJs) – a kind of electrical couplings very intensively between the same type of interneurons. In our previous studies, we reported the theoretical possibility that a class of neuron systems may exhibit spatio-temporal chaos when they are coupled by GJs, while the individual neurons, when isolated, exhibit only simple repetitive firings. This dynamics is emergent, and unveils only when cells are coupled by GJs. Mathematically, this phenomenon could be an expression of chaotic itinerancy among pseudo-attractors (or,attractor ruins). In view of the ubiquity of GJs – there areat leastfive distinct interneuron systems coupled by GJs in the six layers of the neocortex, and in view of the significance of the concept of chaotic itinerancy in memory dynamics we give in this lecture a review about general property and collective dynamics of GJ-coupled neuronal systems.