LOX-induced lipid peroxidation mechanism responsible for the detrimental effect of marine diatoms on Zooplankton grazers
LOX-induced lipid peroxidation mechanism responsible for the detrimental effect of marine diatoms on Zooplankton grazers
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DOI：
10.1002/cbic.200700269
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发表时间：
2007-10-15
期刊：
影响因子：
3.2
通讯作者：
Ianora, Adrianna
中科院分区：
文献类型：
--
作者：
Fontana, Angelo;d'Ippolito, Giuliana;Ianora, Adrianna
一些海洋硅藻会对桡足类等浮游食草动物的繁殖产生负面影响，从而损害通过海洋食物链的能量转移。本文研究了三种水华形成微藻导致硅藻毒性的代谢机制。我们表明，高活性氧（hROS）和硅藻产品的混合混合物（包括脂肪酸氢过氧化物（FAH））可以诱导桡足类功能障碍；这些化合物具有致畸和促凋亡的特性。该过程是由脂氧合酶活性的早期启动引发的，脂氧合酶活性引发物种特异性产物的合成，其基本结构已确定 (1-20)；这些化合物通过大量脂质过氧化作用增强氧化应激。我们的研究可能会解释实验室和现场结果显示，即使在没有多不饱和醛的情况下，硅藻如何损害浮游动物食草动物，多不饱和醛是一类分子，以前被认为与调节硅藻对桡足类的毒性活动有关。
Some marine diatoms negatively affect the reproduction of dominant zooplankton grazers such as copepods, thus compromising the transfer of energy through the marine food chains. In this paper, the metabolic mechanism that leads to diatom-induced toxicity is investigated in three bloom-formin microalgae. We show that copepod dysfunctions can be induced by highly reactive oxygen species (hROS) and a blended mixture of diatom products, including fatty acid hydroperoxides (FAHs); these compounds display teratogenic and proapoptotic properties. The process is triggered by the early onset of lipoxygenase activities that elicit the synthesis of species-specific products, the basic structures of which were established (1-20); these compounds boost oxidative stress by massive lipid peroxidation. Our study might explain post laboratory and field results showing how diatoms damage zooplankton grazers even in the absence of polyunsaturated aldehydes, a class of molecules that has been formerly implicated in mediating the toxic activity of diatoms on copepods.