On the role of blood proteins for uptake, distribution, and clearance of waterborne lipophilic xenobiotics by fish : a linear system analysis
On the role of blood proteins for uptake, distribution, and clearance of waterborne lipophilic xenobiotics by fish : a linear system analysis
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血液蛋白对鱼类吸收、分布和清除水性亲脂性外源物质的作用：线性系统分析
DOI：
10.1016/0045-6535(93)90193-9
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发表时间：
1993
期刊：
影响因子：
8.8
通讯作者：
E. Siré
中科院分区：
文献类型：
--
作者：
B. Streit;E. Siré
在鱼的药代动力学和毒代动力学系统参数，如鳃吸收和消除效率和平均身体停留时间的水生非代谢有机异生物质，定义在线性输入-输出响应理论的框架内。对这些参数的定量估计是结合以下两种方法得出的：（一）逆流鳃模型的精确限流方法;（二）稳态生物浓缩系数的现有相关数据;以及（三）化学化合物的血/水分配系数（β）和辛醇/水分配系数（Kow）。从该模型的预测进行了比较，短期和长期的暴露实验与虹鳟鱼（虹鳟鱼）的经验结果。
Pharmacokinetic and toxicokinetic system parameters in fish, like gill uptake and elimination efficiencies and mean body residence times of waterborne nonmetabolizing organic xenobiotics, are defined within the framework of linear input-output response theory. Quantitative estimates of these parameters derive from combining (i) a refined flow-limited approach of the countercurrent gill model with (ii) available correlation data of the steady state bioconcentration factor (BCFs) as well as (iii) the blood/water partition coefficient (β) with the octanol/water partition coefficient (Kow) of the chemical compound. Predictions from the model are compared to empirical results on short and long term exposure experiments with the rainbow trout (Oncorhynchus mykiss).