Effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs
Effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs
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DOI：
10.2460/ajvr.72.5.634
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发表时间：
2011-05-01
影响因子：
1
通讯作者：
Tagawa, Masahiro
中科院分区：
文献类型：
--
作者：
Ochi, Hiroki;Hara, Yasushi;Tagawa, Masahiro
目的评价长期服用卡洛芬对犬胫骨截骨愈合的影响。动物-12只健康雌性比格犬。程序-对每只犬进行右胫骨中骨干横向截骨术（用髓内钉稳定）。卡洛芬组（n = 6只狗）接受卡洛芬（2.2 mg/kg，口服，每12小时一次）120天；对照组（6）不接受任何治疗。随着时间的推移，通过放射学评估骨愈合和愈伤组织面积的变化。手术后120天对狗实施安乐死，并对胫骨进行生物力学和组织学评估。结果-在手术后120天获得的X光照片上，对照组的截骨线不明显。相比之下，卡洛芬组的截骨线仍然明显。术后 20、30 和 60 天，卡洛芬组的愈伤组织面积明显小于对照组。术后120天，卡洛芬组的刚度、弹性模量和弯曲刚度显着低于对照组的相应值。此外，组织学评估显示，卡洛芬组愈伤组织内的软骨面积显着大于对照组。 结论和临床相关性——长期服用卡洛芬似乎会抑制接受胫骨截骨术的狗的骨愈合。我们建议在治疗与成骨减少相关的愈合延迟的骨折以及与易导致动物骨修复延迟的疾病相关的骨折时，谨慎使用卡洛芬。 （美国兽医研究杂志 2011 年；72：634-641）
Objective To evaluate effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs.Animals-12 healthy female Beagles.Procedures-A mid-diaphyseal transverse osteotomy (stabilized with an intramedullary pin) of the right tibia was performed in each dog. The carprofen group (n = 6 dogs) received carprofen (2.2 mg/kg, PO, q 12 h) for 120 days; the control group (6) received no treatment. Bone healing and change in callus area were assessed radiographically over time. Dogs were euthanized 120 days after surgery, and tibiae were evaluated biomechanically and histologically.Results-The osteotomy line was not evident in the control group on radiographs obtained 120 days after surgery. In contrast, the osteotomy line was still evident in the carprofen group. Callus area was significantly less in the carprofen group, compared with the area in the control group, at 20, 30, and 60 days after surgery. At 120 days after surgery, stiffness, elastic modulus, and flexural rigidity in the carprofen group were significantly lower than corresponding values in the control group. Furthermore, histologic evaluation revealed that the cartilage area within the callus in the carprofen group was significantly greater than that in the control group.Conclusions and Clinical Relevance-Long-term administration of carprofen appeared to inhibit bone healing in dogs that underwent tibial osteotomy. We recommend caution for carprofen administration when treating fractures that have delays in healing associated with a reduction in osteogenesis as well as fractures associated with diseases that predispose animals to delays of osseous repair. (Am J Vet Res 2011;72:634-641)