Complex aberrant splicing in the induced pluripotent stem cell?derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation
Complex aberrant splicing in the induced pluripotent stem cell?derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation
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携带 KCNQ1-A344Asp1 突变的长 QT 综合征患者诱导多能干细胞衍生心肌细胞中的复杂异常剪接
DOI：
10.1016/j.hrthm.2018.05.028
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发表时间：
2018
期刊：
影响因子：
5.5
通讯作者：
Yoshida Yos
中科院分区：
文献类型：
--
作者：
Wuriyanghai Yimin;Makiyama Takeru;Sasaki Kenichi;Kamakura Tsukasa;Yamamoto Yuta;Hayano Mamoru;Harita Takeshi;Nishiuchi Suguru;Chen Jiarong;Kohjitani Hirohiko;Hirose Sayako;Yokoi Fumika;Gao Jingshan;Chonabayashi Kazuhisa;Watanabe Ken;Ohno Seiko;Yoshida Yos
Results:We identified seven aberrant RNA variants in A344Aspl-hiPSC-CMs, more complex compared with those in the peripheral lymphocytes. Multi-electrode array analysis revealed that 1 pM isoproterenol significantly prolonged the duration of corrected field potential in・考) 1. 論文内容要旨は, 研究の目的• 方法• 結果• 考察• 結論の順に記載し, 2 千字