Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study.
Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study.
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DOI：
10.1371/journal.pone.0154227
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Ronfani L
中科院分区：
文献类型：
--
作者：
Morassutto C;Monasta L;Ricci G;Barbone F;Ronfani L
尽管子宫内膜异位症和子宫腺肌病非常常见，并且在妇科学和生育方面具有严重的影响，但根据金标准定义，关于子宫内膜异位症和子宫腺肌病的发病率和患病率的数据非常缺乏。在工业化国家，从出现症状到诊断的平均时间仍然在5至10年之间。使用区域集中数据链接系统，我们计算了2011-2013年意大利弗留利·维内西亚·朱利亚地区女性人群中子宫内膜异位症和子宫腺肌病的发病率和患病率。病例定义为出院记录中的新诊断，手术后允许直接观察子宫内膜异位症和子宫腺肌病，有或没有组织学证实。在核实妇女在过去十年中没有被诊断出来后，诊断被认为是“新的”。子宫内膜异位症和子宫腺肌病的发病率在15-50岁的妇女是0.14%。根据发病率估计，患病率为2.00%。子宫腺肌病占所有诊断的28%，在50岁以后变得越来越普遍。我们的研究结果表明子宫内膜异位症和子宫腺肌病的研究不应仅限于绝经前妇女。需要进一步努力提高妇女和保健专业人员的认识，并寻找新的数据联系可能性，以查明未确诊病例。
Despite being quite frequent and having serious implications in terms of symptomatology and fertility, data on incidence and prevalence of endometriosis and adenomyosis following gold standard definitions are dramatically lacking. The average time from onset of symptoms to diagnosis in industrialized countries still ranges from five to ten years. Using the regional centralized data linkage system, we calculated incidence and prevalence of endometriosis and adenomyosis in the female population of Friuli Venezia Giulia region, Italy, for the years 2011–2013. Cases were defined as new diagnoses from hospital discharge records, following procedures allowing direct visualization for endometriosis and hysterectomy for adenomyosis, with or without histological confirmation. Diagnoses were considered “new” after verifying women had not been diagnosed in the previous ten years. Incidence of endometriosis and adenomyosis in women aged 15–50 years is 0.14%. Prevalence, estimated from incidence, is 2.00%. Adenomyosis, representing 28% of all diagnoses, becomes increasingly prevalent after the age of 50 years. Our results shows how the study of both endometriosis and adenomyosis should not be limited to women of premenopausal age. Further efforts are needed to sensitize women and health professional, and to find new data linkage possibilities to identify undiagnosed cases.