Five year follow up of biocolonisable microporous fluorocarbon haptic (BIOKOP) keratoprosthesis implantation in patients with high risk of corneal graft failure
Five year follow up of biocolonisable microporous fluorocarbon haptic (BIOKOP) keratoprosthesis implantation in patients with high risk of corneal graft failure
复制标题
DOI：
10.1136/bjo.2004.046375
复制
发表时间：
2004-12-01
影响因子：
4.1
通讯作者：
Moreno, JMR
中科院分区：
文献类型：
--
作者：
Alió, JL;Mulet, ME;Moreno, JMR
目的：目的：研究人工角膜模型植入后的解剖学和视觉功能，评价术后远期并发症。11例双侧角膜盲患者的11只眼被认为具有穿透性角膜移植术失败的高风险，植入生物定殖Kpro人工角膜（BIOKOP I，FCI，Rantigny，法国），1996年1月至1998年5月。所有患者仅植入一只眼，并随访60个月。结果：人工角膜（BIOKOP I）的视力结果，解剖和功能的稳定性，并发症，和一般性能的人工角膜进行了evaluated.Results：只有36.3%的位置仍然至今。在患者的最后一次就诊中，与术前测试相比，5只眼睛（45.4%）失明，1只眼睛（9.0%）的最佳矫正视力（BCVA）略有改善。6眼（54.5%）在出现术后并发症之前BCVA有所改善。4只眼睛因挤出而用BIOKOP II替换BIOKOP I Kpro。人工角膜在解剖学上保持原位的平均25.5个月，其功能的性能期限被限制到平均22 month.Conclusion：角膜人工角膜（BIOKOP I，II）不提供一个稳定的解剖关系与周围的眼部结构。其恢复视力的能力仅限于植入严重眼表疾病的眼睛的短期术后。
Aim: To study the anatomical and visual performance following implantation of a model of artificial cornea and to evaluate the postoperative long term complications.Methods: 11 eyes of 11 patients with bilateral corneal blindness considered as potentially having high risk of failure of penetrating corneal keratoplasty were implanted with biocolonisable Kpro keratoprosthesis (BIOKOP I, FCI, Rantigny, France) in the period between January 1996 and May 1998. Only one eye was implanted in all patients and followed up for a period of 60 months. The visual outcome, anatomical and functional stability, complications, and the general performance of the keratoprosthesis were evaluated.Results: The keratoprosthesis (BIOKOP I) only 36.3% remained in position to date. In the patients' last visit five eyes (45.4%) were blind and one (9.0%) showed a slight improvement in the best corrected visual acuity (BCVA) in comparison to preoperative tests. Six eyes (54.5%) showed improved BCVA before having postoperative complications. Four eyes underwent replacement of a BIOKOP I Kpro with a BIOKOP II as a result of extrusion. The keratoprostheses remained anatomically in situ for a mean of 25.5 months and their functional performance period was limited to a mean of 22 months.Conclusion: Corneal keratoprosthesis (BIOKOP I, II) does not provide a stable anatomical relation with the surrounding ocular structures. Its ability to restore vision is limited to a short postoperative period in eyes implanted with severe ocular surface disease.