Diversity of native nicotinic receptor subtypes in mammalian brain
Diversity of native nicotinic receptor subtypes in mammalian brain
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DOI：
10.1016/j.neuropharm.2014.11.003
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发表时间：
2015-09
影响因子：
4.7
通讯作者：
M. Zoli;F. Pistillo;C. Gotti
中科院分区：
文献类型：
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作者：
M. Zoli;F. Pistillo;C. Gotti
神经元烟碱乙酰胆碱受体（nAChR）是一个五聚体配体门控阳离子通道的异质性家族，在脑内表达，参与广泛的生理和病理生理过程，其亚型具有共同的基本结构，但其生物物理和药理学特性取决于亚基组成，因此，这对于理解它们在神经系统中的功能和发现新的亚型选择性药物至关重要。新技术的发展和携带缺失或表达功能获得性nAChR亚基的小鼠的产生，近年来，nAChR基因的研究已成为研究nAChR基因结构和功能的重要手段，但目前对nAChR基因的结构和功能的研究还不多见，本文就nAChR基因的结构和功能作一综述，重点是在啮齿动物缰-脚间通路中鉴定的亚型，这是一种参与尼古丁强化和戒断的通路。我们还讨论了最近的研究结果有关表达的原生亚型在灵长类brain.This文章的一部分，题为'烟碱乙酰胆碱受体：从分子生物学认知'特刊。
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes.The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The development of new technologies and the generation of mice carrying deletions or the expression of gain-of-function nAChR subunits, or GFP-tagged receptor genes has allowed thein vivoidentification of complex subtypes and to study the role of individual subtypes in specific cells and complex neurobiological systems but much less is known about which native nAChR subtypes are involved in specific physiological functions and pathophysiological conditions in human brain.We briefly review some recent findings concerning the structure and function of native nAChRs, focussing on the subtypes identified in the rodent habenulo-interpeduncular pathway, a pathway involved in nicotine reinforcement and withdrawal. We also discuss recent findings concerning the expression of native subtypes in primate brain.This article is part of the Special Issue entitled ‘The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition’.