Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
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DOI：
10.1001/archopht.1994.01090150120033
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发表时间：
1994-03
影响因子：
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通讯作者：
R. Wang;S. Podos;J. Serle;P. Lee;A. Neufeld;R. Deschenes
中科院分区：
文献类型：
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作者：
R. Wang;S. Podos;J. Serle;P. Lee;A. Neufeld;R. Deschenes
目的比较马来酸噻吗心安软膏和马来酸噻吗洛尔软膏对食蟹猴青光眼的远期疗效。方法在一项为期5天的研究中，对4只患青光眼的猴眼每天外涂一次ECA软膏，连续7小时测量眼压。在本研究中，ECA软膏的浓度分别为0.5%、1.0%、1.5%或2.5%。在另一项为期30天的研究中，在每天一次外用浓度为0.75%或1.5%的ECA软膏后测量眼压。用0.5%马来酸噻吗洛尔平日给药2次，周末每天给药1次后与眼压进行比较。结果在为期5天的研究中，2.5%ECA软膏的降压效果最好，最大降幅为8.5+/-2.9 mm Hg(均值+/-扫描电子显微镜)。在治疗的第五天，观察到四种浓度中的每一种都有更明显的眼压下降。在为期30天的研究中，1.5%ECA软膏或0.5%马来酸噻吗洛尔分别降低眼压11.5+/-3.7毫米汞柱和14.0+/-4.5毫米汞柱。重复给药后，1.5%ECA软膏对眼压的影响随时间延长而增加。轻度眼睑浮肿，结膜充血和分泌物，在一些最高浓度的治疗眼观察到。在为期30天的研究中，用1.5%ECA软膏治疗30天的四只眼睛中有一只眼睛出现了浅层角膜侵蚀。结论ECA软膏可降低青光眼猴眼的眼压。在所有浓度测试的情况下，这种减少在治疗的第五天就很明显。每天使用1.5%ECA软膏一次所产生的眼压降低与每日两次使用0.5%马来酸噻吗洛尔的效果相当。因此，这类化合物中的药物可能被证明在青光眼治疗中有用。
OBJECTIVE To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma. METHODS In a 5-day study, IOP was measured for 7 hours after once-daily topical applications of ECA ointment to four glaucomatous monkey eyes. For this study, ECA ointment was given in 0.5%, 1.0%, 1.5%, or 2.5% concentrations. In a separate 30-day study, IOP was measured after once-daily topical applications of ECA ointment in concentrations of 0.75% or 1.5%. The results were compared with IOP after the application of 0.5% timolol maleate administered twice daily on weekdays and once daily on weekends. RESULTS In the 5-day study, 2.5% ECA ointment had the greatest effect on lowering IOP, with a maximum reduction of 8.5 +/- 2.9 mm Hg (mean +/- SEM). A more pronounced reduction in IOP was observed on the fifth day of treatment for each of the four concentrations. In the 30-day study, 1.5% ECA ointment or 0.5% timolol maleate reduced IOP as much as 11.5 +/- 3.7 mmHg and 14.0 +/- 4.5 mmHg, respectively. With repetitive dosing, the effect on IOP after using 1.5% ECA ointment increased with time. Mild eyelid edema, conjunctival hyperemia, and discharge were observed in some eyes treated with the highest concentrations. One eye of four treated with 1.5% ECA ointment for 30 days developed a superficial corneal erosion in the 30-day study. CONCLUSIONS The ECA ointment reduced IOP in glaucomatous monkey eyes. This reduction was evident by the fifth day of treatment with all the concentrations tested. The reduction in IOP produced by once-daily treatment with 1.5% ECA ointment was comparable with that of 0.5% timolol maleate administered twice daily. Therefore, drugs in this class of compound may prove to be useful in glaucoma therapy.