Clinical studies of cerebral blood flow in Alzheimer's disease
Clinical studies of cerebral blood flow in Alzheimer's disease
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DOI：
10.1111/j.1749-6632.1997.tb48477.x
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Budinger, TF
中科院分区：
文献类型：
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作者：
Jagust, WJ;Eberling, JL;Budinger, TF
使用单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）对阿尔茨海默病的研究发现，颞叶和顶叶皮质的血弓和葡萄糖代谢减少。在50例接受神经心理学测试和SPECT灌注成像的AD患者中，我们发现额叶和顶叶的灌注与简易精神状态检查的表现之间存在显著相关性，此外，额叶灌注与额叶能力测试的表现之间存在特定相关性。这些发现，虽然表明灌注措施在确定疾病的临床特征的重要性，没有明确定义灌注变化为主要的，因为类似的结果时，已经看到代谢的研究。在一个单独的5例AD患者和16名对照组中，我们使用PET与灌注示踪剂HIPDM，并检查脑血管对二氧化碳吸入的反应性。我们发现，在多个大脑区域，包括颞叶，AD患者显示出对二氧化碳的反应性灌注的稳健和显著增加，与对照组中观察到的反应没有差异。综上所述，这些结果表明，虽然灌注变化在AD中很重要，但它们并不是原发性的或限制性的。
Studies of Alzheimer's disease using single-photon emission computed tomography (SPECT) and positron emission tomography (PET) have found reductions in blood Bow and glucose metabolism in temporal and parietal cortex. In 50 AD patients who underwent neuropsychological testing and SPECT perfusion imaging, we found significant correlations between perfusion and performance on the Mini-Mental Status Examination in the frontal and parietal lobes, In addition, specific correlations between perfusion in the frontal lobes and performance on tests of frontal lobe ability were noted. These findings, while suggesting the importance of perfusion measures in determining clinical features of the disease, do not clearly define perfusion changes as primary, since similar findings have been seen when metabolism is studied. In a separate group of 5 AD patients and 16 controls, we used PET with the perfusion tracer HIPDM and examined cerebrovascular reactivity to carbon dioxide inhalation, We found that in multiple brain regions, including the temporal lobes, AD patients showed robust and significant increases in perfusion in response to carbon dioxide that did not differ from the response seen in the controls. Taken together, these results show that while perfusion changes are important in AD, they are not clearly either primary or limiting.