Association of Inter-arm Blood Pressure Difference with Asymptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
Association of Inter-arm Blood Pressure Difference with Asymptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
复制标题
高血压患者臂间血压差与无症状颅内、颅外动脉狭窄的关系
DOI：
10.1038/srep29894
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发表时间：
2016-07-14
影响因子：
4.6
通讯作者：
Zhu D
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang J;Qian Y;Tang X;Ling H;Chen K;Li Y;Gao P;Zhu D
臂间血压（BP）差异与缺血性卒中相关。中风的局部动脉粥样硬化在易感个体中存在差异，而颅内动脉狭窄（ICAS）在亚洲人中更常见，颅外动脉狭窄（ECAS）在白人中更常见。本研究旨在探讨中国人群中无卒中高血压患者臂间血压差异与ICAS和ECAS的关系。所有885例患者均通过CT血管造影评估ICAS和ECAS。采用Vascular Profiler-1000型血压测量仪同时测量双侧血压。在连续研究中，ICAS与年龄、男性、平均肱动脉SBP、糖尿病、抗高血压治疗和臂间DBP差显著相关。ECAS与年龄、臂间SBP和LDL相关。在分类研究中，组间DBP差异（≥4 mmHg）的前四分位数的受试者显示ICAS风险显著较高（OR = 2.109; 95% CI，1.24-3.587）。臂间收缩压差值在前四分位数（≥6 mmHg）的受试者发生ECAS的风险显著增高（OR = 2.288; 95%CI，1.309-3.998）。总之，我们报告了臂间收缩压/舒张压差异与ICAS/ECAS的不同相关性。DBP组间差异可能是中国人群ICAS的早期标志，需要长期队列研究进一步验证。
Inter-arm blood pressure (BP) difference has been associated with ischemic stroke. Local atherosclerosis of stroke differ among vulnerable individuals, whereas intracranial arterial stenosis (ICAS) is more frequently affected Asians and extracranial arterial stenosis (ECAS) is more prevalent among whites. We hereby sought to explore the association of inter-arm BP difference with ICAS and ECAS in stroke-free hypertensive patients in Chinese population. All the 885 subjects were evaluated of ICAS and ECAS through computerized tomographic angiography. Both arm BP was measured simultaneously by Vascular Profiler-1000 device. In the continuous study, ICAS was significantly associated with age, male, average brachial SBP, diabetes, anti-hypertensive treatment and inter-arm DBP difference. ECAS was associated with age, inter-arm SBP and LDL. In the categorical study, subjects with the top quartile of inter-arm DBP difference (≥4 mmHg) showed significantly higher risk of ICAS (OR = 2.109; 95% CI, 1.24–3.587). And the participants with the top quartile of inter-arm SBP difference (≥6 mmHg) showed significantly higher risk of ECAS (OR = 2.288; 95% CI, 1.309–3.998). In conclusion, we reported a diverse association of inter-arm SBP/DBP difference with the ICAS/ECAS. Inter-arm DBP difference might be the early symbol of ICAS in Chinese population, which need further verification in long-term cohort study.