A 1-Mb bacterial clone contig spanning the endometrial cancer deletion region at 1p32-p33.
A 1-Mb bacterial clone contig spanning the endometrial cancer deletion region at 1p32-p33.
复制标题
跨越子宫内膜癌 1p32-p33 缺失区域的 1 Mb 细菌克隆重叠群。
DOI：
10.1006/geno.1999.5652
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Goodfellow,PJ
中科院分区：
文献类型：
--
作者：
Arlt,MF;Li,M;Herzog,TJ;Goodfellow,PJ
Our laboratory previously reported a high frequency of loss of heterozygosity (LOH) at 1p32–p33 in endometrial cancers. LOH at 1p32–p33 is a specific feature of one of the most aggressive forms of endometrial carcinoma, uterine papillary serous cancer (UPSC). The minimum region of allelic loss in UPSC is defined by D1S190 and D1S447, an interval corresponding to less than 1 cM. Here we describe the construction and characterization of a sequence-ready clone contig that spans the deletion region. The contig consists of 24 bacterial artificial chromosome clones and 18 P1 artificial chromosome clones and spans approximately 1050 kb. The consensus region of allelic loss between D1S190 and D1S447 represents approximately 792 kb. Eight previously described ESTs have been positioned within the contig.
