Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers.
Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers.
复制标题
哺乳动物 C 型逆转录病毒增强子中结合多个序列的蛋白质的表征。
DOI：
10.1128/jvi.67.4.1976-1986.1993
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发表时间：
1993
影响因子：
5.4
通讯作者：
Speck,NA
中科院分区：
文献类型：
--
作者：
Sun,W;O'Connell,M;Speck,NA
Mammalian type C retrovirus enhancer factor 1 (MCREF-1) is a nuclear protein that binds several directly repeated sequences (CNGGN6CNGG) in the Moloney and Friend murine leukemia virus (MLV) enhancers (N. R. Manley, M. O'Connell, W. Sun, N. A. Speck, and N. Hopkins, J. Virol. 67:1967-1975, 1993). In this paper, we describe the partial purification of MCREF-1 from calf thymus nuclei and further characterize the binding properties of MCREF-1. MCREF-1 binds four sites in the Moloney MLV enhancer and three sites in the Friend MLV enhancer. Ethylation interference analysis suggests that the MCREF-1 binding site spans two adjacent minor grooves of DNA.
