Discovery of biomarkers that reflect the intake of sodium selenate by nutritional proteomics.
Discovery of biomarkers that reflect the intake of sodium selenate by nutritional proteomics.
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通过营养蛋白质组学发现反映硒酸钠摄入量的生物标志物。
DOI：
10.1093/chromsci/47.9.840
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发表时间：
2009
影响因子：
1.3
通讯作者：
M. Zamorano
中科院分区：
文献类型：
--
作者：
A. Mahn;M. C. Muñoz;M. Zamorano
硒具有重要的健康益处，包括预防某些类型的癌症。传统的硒指标，如硒浓度，不能说明这种元素的代谢状态，就其化学保护作用。然后，一组蛋白质的知识，响应硒补充可能是有用的硒的代谢状态的评估。研究了膳食补充硒酸钠对大鼠血浆蛋白质组的影响。由六只大鼠组成的一组被喂食以每克食物中1.9微克硒的硒酸钠补充的基本饮食，并且对照组被喂食覆盖最低硒需求的饮食，各持续十周。一个蛋白质组学的方法是用来量化的变化，一些血浆蛋白质的丰度，并确定它们。纤维蛋白原，载脂蛋白，结合珠蛋白，甲状腺素运载蛋白改变显着的丰度，由于硒管理。这些蛋白质与硒代谢间接相关。因此，补硒后蛋白质组的变化有可能成为评价硒代谢状况的一个新指标。该指数可能有助于通过营养诊断预防某些疾病，从而提供适当的饮食建议。
Selenium offers important health benefits, including the prevention of some types of cancer. The traditional selenium indexes, such as selenium concentration, do not account for the metabolic status of this element regarding its chemoprotective effect. Then, the knowledge of a group of proteins that respond to selenium supplementation could be useful in the assessment of the metabolic status of selenium. The effect of dietary supplementation of rats with sodium-selenate on the blood plasma proteome is investigated. A group composed of six rats is fed a basic diet supplemented with sodium-selenate at 1.9 microg of Selenium per g of food, and a control group is fed a diet that covers the minimum selenium requirements, each for ten weeks. A proteomic approach is used to both quantify the changes in the abundance of some plasmatic proteins and to identify them. Fibrinogen, apolipoproteins, haptoglobin, and transthyretin changed significantly their abundance due to selenium administration. Those proteins are indirectly related to selenium metabolism. Then, the change in the proteomic profile due to selenium supplementation could probably be considered as a new index to assess the metabolic status of selenium. This index might help in the prevention of some diseases by nutritional diagnosis and, consequently, the adequate dietary recommendation.
大鼠纤维蛋白原 B β 链 cDNA 完整编码序列的克隆：纤维蛋白 β 15-42 一级结构的种间保守性。
DOI：
--
发表时间：
1994
期刊：
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
影响因子：
--
作者：
Courtney,MA;Bunce,LA;Neroni,LA;Simpson-Haidaris,PJ
通讯作者：
Simpson-Haidaris,PJ
DOI：
10.1046/j.1464-410x.1998.00630.x
发表时间：
1998-05
期刊：
British journal of urology
影响因子：
--
作者：
L. Clark;Bruce L. Dalkin;A. Krongrad;G. Combs;B. Turnbull;E. Slate;R. Witherington;Herlong Jh
通讯作者：
L. Clark;Bruce L. Dalkin;A. Krongrad;G. Combs;B. Turnbull;E. Slate;R. Witherington;Herlong Jh