Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors.
Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors.
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DOI：
10.1038/srep28325
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发表时间：
2016-06-21
影响因子：
4.6
通讯作者：
Shi X
中科院分区：
文献类型：
--
作者：
Hu Y;Wang R;Wang S;Ding L;Li J;Luo Y;Wang X;Shen M;Shi X
我们在此报告了多功能叶酸（FA）靶向Fe3O4 @ Au纳米星（NSs）的开发，用于肿瘤的靶向多模式磁共振（MR）/计算机断层扫描（CT）/光声（PA）成像和光热疗法（PTT）。在本研究中，通过温和还原途径制备的柠檬酸稳定的 Fe3O4/Ag 复合纳米粒子被用作种子，并暴露于 Au 生长溶液中，以诱导 Fe3O4 @ Au 核/壳 NSs 的形成。随后通过聚乙二醇间隔基对硫醇化聚乙烯亚胺（PEI-SH）、FA 进行连续修饰，并对残留的 PEI 胺进行乙酰化，形成多功能 Fe3O4 @ Au NSs。设计的多功能NSs具有优异的胶体稳定性、在给定浓度范围内良好的细胞相容性以及对过表达FA受体的癌细胞的特异性识别。由于Fe3O4核和星形Au壳的共存，NSs可分别用于肿瘤的MR和CT成像。同样，近红外等离子体吸收特性也使得 NS 可用于肿瘤的 PA 成像和 PTT。我们的研究清楚地证明了一种独特的治疗诊断纳米平台，可用于高性能多模式成像引导的肿瘤 PTT，这可能可扩展到转化医学中不同疾病的治疗诊断。
We herein report the development of multifunctional folic acid (FA)-targeted Fe3O4 @ Au nanostars (NSs) for targeted multi-mode magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging and photothermal therapy (PTT) of tumors. In this present work, citric acid-stabilized Fe3O4/Ag composite nanoparticles prepared by a mild reduction route were utilized as seeds and exposed to the Au growth solution to induce the formation of Fe3O4 @ Au core/shell NSs. Followed by successive decoration of thiolated polyethyleneimine (PEI-SH), FA via a polyethylene glycol spacer, and acetylation of the residual PEI amines, multifunctional Fe3O4 @ Au NSs were formed. The designed multifunctional NSs possess excellent colloidal stability, good cytocompatibility in a given concentration range, and specific recognition to cancer cells overexpressing FA receptors. Due to co-existence of Fe3O4 core and star-shaped Au shell, the NSs can be used for MR and CT imaging of tumors, respectively. Likewise, the near infrared plasmonic absorption feature also enables the NSs to be used for PA imaging and PTT of tumors. Our study clearly demonstrates a unique theranostic nanoplatform that can be used for high performance multi-mode imaging-guided PTT of tumors, which may be extendable for theranostics of different diseases in translational medicine.