Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke
Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke
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DOI：
10.1160/th03-11-0690
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发表时间：
2004-05-01
影响因子：
6.7
通讯作者：
Estellés, A
中科院分区：
文献类型：
--
作者：
Aznar, J;Mira, Y;Estellés, A
V 因子 Leiden (FVL) 和凝血酶原 G20210A (PT 20210) 突变与缺血性中风之间的关联仍存在争议，特别是在患有隐源性中风的年轻人中。在 49 名 50 岁以下的隐源性中风患者中评估了 FVL (4.1%) 和 PT 20210 (8.2%) 突变的患病率，并与对照组进行了比较。 FVL 的隐源性卒中的比值比 (OR) 为 2.62 (95% CI, 0.49-13.95)，PT 20210 的比值比 (OR) 为 3.75 (95% CI, 1.05-13.34)，某些公认的遗传性血栓形成缺陷的比值比 (OR) 为 3.28 (95% CI, 1.17-9.20)。此外，使用口服避孕药 (OC) 的年轻女性发生隐源性卒中的 OR 为 3.59（95% CI，1.28-10.5）。当某些遗传性血栓形成缺陷与 OC 相关时，OR 更高（OR：14.27；95% CI，0.66-309.99）。我们的结果表明，在地中海人群中，PT 20210 突变（而非 FV Leiden）是年轻人隐源性中风的危险因素。使用口服避孕药也是隐源性中风的一个重要危险因素，在具有某些遗传性血栓形成危险因素的女性中，隐源性中风的发生率更高。
The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke. Prevalence of FVL (4.1%) and PT 20210 (8.2%) mutations was assessed in 49 patients under 50 years with cryptogenic stroke and compared with controls. Odd ratio (OR) for cryptogenic stroke was 2.62 (95% CI, 0.49-13.95) for FVL and 3.75 (95% CI, 1.05-13.34) for PT 20210 and 3.28 (95% CI, 1,17-9.20) for some recognized genetic thrombophilic defect. Moreover, the OR for cryptogenic stroke in young women using oral contraceptives (OC) was 3.59 (95% CI, 1.28-10.5). When some genetic thrombophilic defect was associated with OC, the OR was much higher (OR: 14.27; 95% CI, 0.66-309.99). Our results suggest that in the Mediterranean populations the PT 20210 mutation, but not FV Leiden, is a risk factor for cryptogenic stroke in young adults. OC use is also a significant risk factor for cryptogenic stroke, which is increased in women with some genetic thrombotic risk factor.