Maternal ethnicity and pre-eclampsia in New York City, 1995-2003
Maternal ethnicity and pre-eclampsia in New York City, 1995-2003
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DOI：
10.1111/j.1365-3016.2011.01222.x
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Engel, Stephanie M.
中科院分区：
文献类型：
--
作者：
Gong, Jian;Savitz, David A.;Engel, Stephanie M.
关于先兆子痫风险的种族差异的研究有限。我们将纽约市1995-2003年期间902460例单胎分娩的出生记录与出院数据联系起来，以评估种族与先兆子痫风险之间的关系，并比较美国出生和外国出生妇女的风险。Logistic回归模型调整了母亲的年龄，母亲的教育，产次，自我报告的孕前母亲的体重，在怀孕期间吸烟和分娩年份进行比较，每个种族组与非西班牙裔白色妇女。本研究人群中先兆子痫的患病率为3.2%。在我们的研究中考虑的主要种族群体中，东亚妇女患先兆子痫的风险最低（1.4%），墨西哥妇女的风险最高（5.0%）。与非西班牙裔白色女性相比，东亚女性的风险略有降低（调整后OR = 0.8，[95% CI 0.7，0.8]），北非女性的风险相似（调整后OR = 1.1，[95% CI 0.9，1.3]），所有其他主要种族组的风险增加（调整后OR：1.3，2.9），墨西哥女性的风险最高（调整后OR = 2.9，[95% CI 2.7，3.1]）。除了在国外出生的东南亚和太平洋岛民相对于在美国出生的女性，先兆子痫的风险增加（调整后OR = 1.8，[95% CI 1.0，3.1]）外，未观察到美国与外国出生的女性的风险差异。我们的结论是，在纽约市的妇女中，先兆子痫的发展存在种族异质性，在未来的种族研究中，亚洲亚组应单独进行研究。我们的研究结果应有助于筛选先兆子痫考虑种族差异，并可能有助于提出线索的病因学研究条件。
Studies on ethnic differences in the risk of pre-eclampsia are limited. We linked birth records for 902 460 singleton births for the period 1995-2003 in New York City with hospital discharge data to evaluate the association between ethnicity and the risk of pre-eclampsia and compare risks between US-born and foreign-born women. Logistic regression models adjusted for maternal age, maternal education, parity, self-reported pre-pregnancy maternal weight, smoking during pregnancy and year of delivery were used to compare each ethnic group with non-Hispanic White women. The prevalence of pre-eclampsia in this study population was 3.2%. Among the major ethnic groups considered in our study, East Asian women had the lowest risk of pre-eclampsia (1.4%) and Mexican women had the highest risk (5.0%). Compared with non-Hispanic White women, there was a slightly decreased risk for East Asian women (adjusted OR = 0.8, [95% CI 0.7, 0.8]), similar risk for North African women (adjusted OR = 1.1, [95% CI 0.9, 1.3]), and increased risk for all other major ethnic groups (adjusted ORs: 1.3, 2.9), with the highest risk for Mexican women (adjusted OR = 2.9, [95% CI 2.7, 3.1]). No difference in risks was observed for US-vs. foreign-born women with the exception that foreign-born South-East Asian and Pacific Islanders had an increased risk of pre-eclampsia (adjusted OR = 1.8, [95% CI 1.0, 3.1]) relative to those born in the US. We concluded that there was ethnic heterogeneity in the development of pre-eclampsia among women in New York City and that Asian subgroups should be examined separately in future studies on ethnicity. Our results should contribute to screening for pre-eclampsia taking ethnic variation into account, and may help to suggest leads for the study of the aetiology of the condition.