Could cortical signals control intraspinal stimulators? A theoretical evaluation
Could cortical signals control intraspinal stimulators? A theoretical evaluation
复制标题
DOI：
10.1109/tnsre.2006.875532
复制
发表时间：
2006-06-01
影响因子：
4.9
通讯作者：
Saigal, Rajiv
中科院分区：
文献类型：
--
作者：
Mushahwar, Vivian K.;Guevremont, Lisa;Saigal, Rajiv
在这篇文章中，我们研究了使用两种不同的脊髓内微刺激(ISMS)范例产生步进所需的控制信号，并讨论了使用脑机接口控制ISMS诱发步进的理论可行性。强直(恒幅)和相位(调制幅度)ISMS方案被用来在瘫痪猫的后肢产生台阶。低幅度紧张性刺激激活了一个类似脊髓运动的网络，导致后肢双侧行走。阶段性刺激通过同时激活一侧肢体的屈肌协同作用和另一侧肢体的伸肌协同作用来产生协调的步态。利用这些ISMS范式，我们提出一个或两个独立的皮质信号将足以控制脊髓损伤后ISMS诱导的步进。
In this paper, we examine the control signals that are required to generate stepping using two different intraspinal microstimulation (ISMS) paradigms and discuss the theoretical feasibility of controlling ISMS-evoked stepping using a brain computer interface. Tonic (constant amplitude) and phasic (modulated amplitude) ISMS protocols were used to produce stepping in the hind limbs of paralyzed cats. Low-amplitude tonic ISMS activated a spinal locomotor-like network that resulted in bilateral stepping of the hind limbs. Phasic ISMS generated coordinated stepping by simultaneously activating flexor synergies in one limb coupled with extensor synergies in the other. Using these ISMS paradigms, we propose that one or two independent cortical signals will be adequate for controlling ISMS-induced stepping after SCI.