Positive and negative aspects of participation in illicit drug research: Implications for recruitment and ethical conduct
Positive and negative aspects of participation in illicit drug research: Implications for recruitment and ethical conduct
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DOI：
10.1016/j.drugpo.2006.07.001
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发表时间：
2007-05-01
影响因子：
4.4
通讯作者：
Fry, Craig L.
中科院分区：
文献类型：
--
作者：
Barratt, Monica J.;Norman, Josephine S.;Fry, Craig L.
加深对吸毒者参与研究的激励措施和障碍的理解，可改善研究招募、保留和结果，并提高非法药物研究在伦理上的可接受性。在澳大利亚的墨尔本，2001-2004年期间，从针头和注射器方案中招募了507名注射毒品使用者，并要求他们提名研究中“最好”和“最坏”的事情。通常报告的药物研究的积极方面是其提供有关药物使用的有效信息的能力（39%），改进药物相关政策和做法的潜力（20%）和对社区的好处（14%）。报告的药物研究的负面方面包括对研究结果缺乏或负面影响的担忧（31%），以及对研究项目的个人厌恶，如不适（27%），不便（21%）和风险（9%）。注射吸毒者可能会参加非干预性研究，因为预期对自己和他人有好处，也可能会因个人不适、不便和风险，或认为缺乏影响或好处而不愿参与。为了加强非干预性研究的招募并履行伦理义务，研究者应（1）积极考虑如何最大限度地减少研究中IDU定义的负面影响，（2）向潜在参与者澄清研究对政策和实践的预期影响。(c)2006 Elsevier B. V.保留所有权利。
Improved understanding of incentives and barriers to drug user research participation may improve study recruitment, retention and outcomes and enhance the ethical acceptability of illicit drug research. In Melbourne, Australia during 2001-2004, 507 injecting drug users were recruited from Needle and Syringe Programs and asked to nominate the 'best' and 'worst' things about research. Commonly reported positive aspects of drug research were its capacity to provide valid information about drug use (39%), the potential to improve drug-related policies and practices (20%) and benefits to the community (14%). Reported negative aspects of drug research included concerns about lack of, or negative impact of research findings (31%), and personal dislikes about research projects, such as discomfort (27%), inconvenience (21%) and risk (9%). IDU may participate in non-intervention research because of expected benefits for themselves and others, and may be discouraged from involvement by personal discomfort, inconvenience and risk, or a perceived lack of impact or benefit. To enhance recruitment to non-intervention research and fulfil ethical obligations investigators should (1) actively consider how best to minimise the IDU-defined negative aspects of research, and (2) clarify for prospective participants the intended impact of the research on policy and practice. (c) 2006 Elsevier B.V. All rights reserved.