Helical screw sense of peptide molecules: The pentapeptide system (Aib)4/L-Val[L-(αMe)Val] in the crystal state
Helical screw sense of peptide molecules: The pentapeptide system (Aib)4/L-Val[L-(αMe)Val] in the crystal state
复制标题
肽分子的螺旋感：晶态五肽系统(Aib)4/L-Val[L-(αMe)Val]
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
J. Kamphuis
中科院分区：
文献类型：
--
作者：
E. Benedetti;M. Saviano;R. Iacovino;C. Pedone;A. Santini;M. Crisma;F. Formaggio;C. Toniolo;Q. Broxterman;J. Kamphuis
用X-射线衍射法研究了六种Nα-封闭五肽酯的结晶择优构象，它们分别含有四个非手性α-氨基异丁酸（Aib）残基和一个手性L-缬氨酸（L-瓦尔）或Cα-甲基-L-缬氨酸[（αMe）瓦尔]残基。在所有化合物中，（Aib）4序列以规则的310-螺旋构象折叠。在以L-（αMe）瓦尔残基为特征的四个五肽中，两个构象不同的分子出现在不对称单元中。相反，在具有C-末端L-Val残基的两个五肽的不对称单元中仅观察到一个分子。在基于L-瓦尔的肽中，（Aib）4序列的螺旋螺旋方向是右手的，而在L（αMe）瓦尔类似物中，右旋和左旋螺旋方向同时出现在两个晶体学独立的分子中。John Wiley & Sons，Inc. Biopoly 46：433-443，1998年
The crystal-state preferred conformations of six Nα-blocked pentapeptide esters, each containing four helicogenic, achiral α-aminoisobutyric acid (Aib) residues followed by one chiral L-valine (L-Val) or Cα-methyl-L-valine [(αMe)Val] residue at the C-terminus, have been assessed by x-ray diffraction analysis. In all of the compounds the (Aib)4 sequence is folded in a regular 310-helical conformation. In the four pentapeptides characterized by the L-(αMe)Val residue two conformationally distinct molecules occur in the asymmetric unit. Conversely, only one molecule is observed in the asymmetric unit of two pentapeptides with the C-terminal L-Val residue. In the L-Val based peptides the helical screw sense of the (Aib)4 sequence is right-handed, whereas in the L(αMe)Val analogues both right- and left-handed helical screw senses concomitantly occur in the two crystallographically independent molecules. © 1998 John Wiley & Sons, Inc. Biopoly 46: 433–443, 1998
影响因子：
2.9
作者：
KARLE, IL;BALARAM, P
通讯作者：
BALARAM, P
DOI：
10.1111/j.1399-3011.1983.tb02062.x
发表时间：
1983
期刊：
International journal of peptide and protein research
影响因子：
--
作者：
Benedetti,E;Morelli,G;Némethy,G;Scheraga,HA
通讯作者：
Scheraga,HA