Cancer: A matter of life cycle?
Cancer: A matter of life cycle?
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DOI：
10.1016/j.cellbi.2007.08.013
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发表时间：
2007-12-01
影响因子：
3.9
通讯作者：
Cragg, Mark S.
中科院分区：
文献类型：
--
作者：
Erenpreisa, Jekaterina;Cragg, Mark S.
在过去的十年里，“癌症干细胞”的概念出现了，人们认识到只有一小部分肿瘤细胞似乎保留了自我更新和无限增殖的干细胞特性。同时，众所周知，癌症是一种与年龄有关的疾病，发生在细胞增殖衰老的极限。将衰老和自我更新能力联系起来的明显需求使得一些作者提出，癌症是从衰老干细胞中发展而来的。然而，最近Sundaram M， Guernsey DL, Rajaraman MM， Rajaraman R [Neosis：一种新型的癌症细胞分裂]提出了另一种解决方案。癌症杂志2004；[03:20 7-18]，他们认为严厉可能是一种短暂的、周期性的特性，是由经历了多倍体化的衰老细胞的去多倍体化所提供的。在这篇综述中，我们试图调和这两种观点，认为循环多倍体间歇性衰老和返老返老可能是生命周期的特征，类似于某些单细胞生物的生命周期。此外，我们认为有丝分裂灾难可能代表了一种机制，通过这种机制，细胞可以从通常的有丝分裂细胞周期切换到这种进化上保守的生命周期。有趣的是，最近的一些数据表明，细胞衰老可能是可逆的，干细胞对基因毒性应激引起的多倍体具有耐受性。(c) 2007年国际细胞生物学联合会。Elsevier Ltd.出版。版权所有。
In the last decade, the concept of "cancer stem cells" has emerged, recognised by the fact that only a small fraction of tumour cells appears to retain the stem cell properties of self-renewal and unlimited proliferation. At the same time, it is well known that cancer is an age-related disease developing at the limit of proliferating cell senescence. The apparent need to link senescence and the capacity for self-renewal has lead some authors to suggest that cancers develop from amongst senescing stem cells. However, an alternative solution has recently been proffered by Sundaram M, Guernsey DL, Rajaraman MM, Rajaraman R [Neosis: a novel type of cell division in cancer. Cancer Biol Ther 2004;3:207-18], who suggest that sternness may be a transient, cyclic property afforded by de-polyploidisation of senescing cells which have undergone polyploidisation. In this mini-review, we attempt to reconcile both of these views by the idea that cycling polyploidy intermitting senescence and rejuvenation may be features of a life cycle analogous to the life cycles of certain unicellular organisms. Furthermore, we suggest that mitotic catastrophe may represent a mechanism through which the cell can switch from the usual mitotic cell-cycle to this evolutionarily conserved life cycle. Intriguingly, some most recent data suggest that cell senescence may be reversible and that stem cells are tolerant to polyploidy caused by genotoxic stress. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.