Molecular targets of psychedelic-induced plasticity.
Molecular targets of psychedelic-induced plasticity.
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致幻剂诱导可塑性的分子靶点。
DOI：
10.1111/jnc.15536
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发表时间：
2022-07
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
不同学科和生物水平的迷幻研究正在以惊人的速度增长。在迷幻药再次成为被批准的治疗的前景中，这些努力中的大部分已经定向于探索实际迷幻效果与那些治疗兴趣的表现之间的关系。考虑到5-羟色胺5-HT 2A受体在致幻剂对人类精神的不同影响中的核心作用，神经药理学处于这一争论和探索连续体的中心。在这里，我们讨论了一些最新的研究结果，在人类研究和背景下考虑以前的临床前模型研究突触可塑性相关的现象。特别强调的是知识差距，挑战和限制，以评估迷幻剂的潜在抗抑郁作用的基础。
Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action.