Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich.
Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich.
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DOI：
10.3390/ijerph18073572
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发表时间：
2021-03-30
影响因子：
--
通讯作者：
On Behalf Of The KoCo Study Group
中科院分区：
文献类型：
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作者：
Pritsch M;Radon K;Bakuli A;Le Gleut R;Olbrich L;Guggenbüehl Noller JM;Saathoff E;Castelletti N;Garí M;Pütz P;Schälte Y;Frahnow T;Wölfel R;Rothe C;Pletschette M;Metaxa D;Forster F;Thiel V;Rieß F;Diefenbach MN;Fröschl G;Bruger J;Winter S;Frese J;Puchinger K;Brand I;Kroidl I;Hasenauer J;Fuchs C;Wieser A;Hoelscher M;On Behalf Of The KoCo Study Group
鉴于大量的轻度或无症状SARS-CoV-2病例，只有基于人群的研究才能对大流行的规模提供可靠的估计。因此，我们的目的是评估SARS-CoV-2在慕尼黑普通人群中的血清流行率。为此，我们抽取了2994个私人家庭的代表性样本，并邀请14岁及以上的家庭成员填写问卷并提供血液样本。SARS-CoV-2血清阳性定义为Roche N pan-Ig ≥ 0.4218。我们调整了抽样设计、敏感性和特异性的患病率。我们通过广义线性混合模型和排列检验研究了SARS-CoV-2血清阳性和地理空间传播模式的危险因素。SARS-CoV-2特异性抗体的血清阳性率为1.82%（95%置信区间（CI）1.28-2.37%），而慕尼黑正式登记的PCR阳性病例为0.46%。嗅觉或味觉丧失与血清阳性（比值比（OR）47.4; 95%CI 7.2-307.0）和家庭内聚集性感染相关。通过这一首次在未受超级传播事件影响的德国大城市进行的SARS-CoV-2流行率基于人群的研究，我们可以表明，私人家庭中至少有四分之一的病例被报告并为卫生当局所知。这些结果将有助于当局估计人口中疾病的真实负担，并就公共卫生措施采取循证决策。
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates of the magnitude of the pandemic. We therefore aimed to assess the sero-prevalence of SARS-CoV-2 in the Munich general population after the first wave of the pandemic. For this purpose, we drew a representative sample of 2994 private households and invited household members 14 years and older to complete questionnaires and to provide blood samples. SARS-CoV-2 seropositivity was defined as Roche N pan-Ig ≥ 0.4218. We adjusted the prevalence for the sampling design, sensitivity, and specificity. We investigated risk factors for SARS-CoV-2 seropositivity and geospatial transmission patterns by generalized linear mixed models and permutation tests. Seropositivity for SARS-CoV-2-specific antibodies was 1.82% (95% confidence interval (CI) 1.28–2.37%) as compared to 0.46% PCR-positive cases officially registered in Munich. Loss of the sense of smell or taste was associated with seropositivity (odds ratio (OR) 47.4; 95% CI 7.2–307.0) and infections clustered within households. By this first population-based study on SARS-CoV-2 prevalence in a large German municipality not affected by a superspreading event, we could show that at least one in four cases in private households was reported and known to the health authorities. These results will help authorities to estimate the true burden of disease in the population and to take evidence-based decisions on public health measures.
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影响因子：
5
作者：
Sempos, Christopher T.;Tian, Lu
通讯作者：
Tian, Lu
DOI：
10.1016/j.ijid.2020.09.1464
发表时间：
2020-12
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Meyerowitz-Katz G;Merone L
通讯作者：
Merone L
DOI：
10.1016/j.medj.2020.10.003
发表时间：
2021-02-12
期刊：
Med (New York, N.Y.)
影响因子：
--
作者：
Hippich M;Holthaus L;Assfalg R;Zapardiel-Gonzalo J;Kapfelsperger H;Heigermoser M;Haupt F;Ewald DA;Welzhofer TC;Marcus BA;Heck S;Koelln A;Stock J;Voss F;Secchi M;Piemonti L;de la Rosa K;Protzer U;Boehmer M;Achenbach P;Lampasona V;Bonifacio E;Ziegler AG
通讯作者：
Ziegler AG
影响因子：
3.7
作者：
McDade, Thomas W.;McNally, Elizabeth M.;Demonbreun, Alexis R.
通讯作者：
Demonbreun, Alexis R.
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel