Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan
Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan
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DOI：
10.1016/j.vetmic.2019.06.019
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发表时间：
2019-09-01
影响因子：
3.3
通讯作者：
Maeda, Ken
中科院分区：
文献类型：
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作者：
Matsuu, Aya;Momoi, Yasuyuki;Maeda, Ken
严重发热伴血小板减少综合征(SFTS)是新近发现的一种新发传染病。人畜共患病是一种高致死率的人畜共患病，动物感染SFTS病毒(SFTSV)的临床信息十分重要。自2017年以来，我们通过遗传和血清学检测，诊断出24只生活在日本西部的客户拥有的猫患有SFTS。在这项研究中，我们通过回顾评估临床参数，描述了猫SFT的临床特征及其相关的危险因素。并对SFTSV进行了系统发育分析。年龄和性别无明显趋势，室外猫科动物普遍存在感染SFTSV的危险。所有感染的猫都表现出急性发作的临床症状，包括食欲减退和嗜睡，68.2%的猫出现发热，41.7%的猫出现呕吐。病死率为62.5%。首次临床血检的特征表现为血小板减少、白细胞减少、血清总胆红素、血清淀粉样蛋白A和肌酸磷酸激酶浓度升高。系统发育分析表明，地区性聚集性病毒既感染人类，也感染猫。对于宠物主人和动物医院来说，小动物中的SFT可能是一个重要的公共卫生问题。
Severe fever with thrombocytopenia syndrome (SFTS) is a recently discovered emerging infectious disease. A zoonotic disease with a high fatality rate in human beings, clinical information on SFTS virus (SFTSV) infection in animals is important. Since 2017, we have diagnosed 24 client-owned cats living in western Japan with SFTS, by genetic and serological testing. In this study, we characterized the clinical features of SFTS in cats and their associated risk factors, by evaluating the clinical parameters retrospectively. A phylogenetic analysis on SFTSV was also conducted. There were no obvious tendencies in age or sex, outdoor cats were commonly at risk of SFTSV infection. All infected cats showed acute onset of clinical signs including anorexia and lethargy, while 68.2% of the cats showed fever and 41.7% showed vomiting. The case fatality rate was 62.5%. Thrombocytopenia, leukopenia, and elevated serum total bilirubin, serum amyloid A, and creatinine phosphokinase concentration were the characteristic findings in the first clinical blood examination. Phylogenic analysis revealed that regional clustered viruses infect both humans and cats. For pet owners and animal hospitals, SFTS in small animals could be an important public health issue.