Generating electrospray from microchip devices using electroosmotic pumping.
Generating electrospray from microchip devices using electroosmotic pumping.
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DOI：
10.1021/ac971475k
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发表时间：
1997-03
影响因子：
7.4
通讯作者：
R. Ramsey;J. Michael Ramsey
中科院分区：
文献类型：
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作者：
R. Ramsey;J. Michael Ramsey
本发明描述了一种从蚀刻在平面衬底上的小通道流出的溶液产生电喷雾的方法。使用静电感应压力输送流体，并通过施加足够幅度的电势从通道的末端静电喷射，以在微芯片和与通道末端间隔开的导体之间产生电喷雾。除了暴露通道开口之外，不需要对微芯片进行重大修改。描述并演示了调节液体输送的原理。通过将微芯片与离子阱质谱仪耦合，获得连续洗脱的供试化合物碘化四丁基铵的光谱。
A method of generating electrospray from solutions emerging from small channels etched on planar substrates is described. The fluids are delivered using electroosmotically induced pressures and are sprayed electrostatically from the terminus of a channel by applying an electrical potential of sufficient amplitude to generate the electrospray between the microchip and a conductor spaced from the channel terminus. No major modification of the microchip is required other than to expose a channel opening. The principles that regulate the fluid delivery are described and demonstrated. A spectrum for a test compound, tetrabutylammonium iodide, that was continuously electrophoresed was obtained by coupling the microchip to an ion trap mass spectrometer.