Systemic Inflammatory Response and Outcomes in Community-Acquired Pneumonia Patients Categorized According to the Smoking Habit or Presence of Chronic Obstructive Pulmonary Disease.
Systemic Inflammatory Response and Outcomes in Community-Acquired Pneumonia Patients Categorized According to the Smoking Habit or Presence of Chronic Obstructive Pulmonary Disease.
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DOI：
10.3390/jcm9092884
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发表时间：
2020-09-07
影响因子：
3.9
通讯作者：
Torres A
中科院分区：
文献类型：
--
作者：
Crisafulli E;Cillóniz C;Liapikou A;Ferrari M;Busti F;Girelli D;Torres A
全身炎症反应(SIR)有助于预测社区获得性肺炎(CAP)的临床进展、治疗失败和预后。暴露在烟草烟雾中可能会影响SIR；吸烟在CAP中的作用尚未得到巩固。我们评估了根据吸烟习惯和COPD的存在分层的CAP住院患者的SIR和预后。这项回顾分析是在巴塞罗那的医院诊所进行的。在入院时收集基线、临床、微生物学和实验室变量，使用C-反应蛋白(CRP)水平作为SIR的标志。研究结果包括胸膜并发症、住院时间、无创和有创机械通气(IMV)和重症监护病房(ICU)入院。我们还考虑了住院和30天的死亡率。数据按吸烟习惯(非吸烟者、既往吸烟者和当前吸烟者)和COPD的存在进行分组。现在的吸烟者更年轻，合并症更少，以前的肺炎发作也更少。目前吸烟者的CRP水平高于其他组。目前吸烟者发生胸膜并发症的风险较高，与C反应蛋白水平、胸膜疼痛和高血小板计数无关。目前的吸烟者更多地需要IMV和ICU入院。目前的吸烟者有更大的炎症反应，并有更高的胸膜并发症风险。
The systemic inflammatory response (SIR) may help to predict clinical progression, treatment failure, and prognosis in community-acquired pneumonia (CAP). Exposure to tobacco smoke may affect the SIR; the role of smoking in CAP has not been consolidated. We evaluated the SIR and outcomes of hospitalized CAP patients stratified by smoking habits and the presence of COPD. This retrospective analysis was conducted at the Hospital Clinic of Barcelona. Baseline, clinical, microbiological, and laboratory variables were collected at admission, using C-reactive protein (CRP) levels as a marker of SIR. The study outcomes were pleural complications, hospital stay, non-invasive and invasive mechanical ventilation (IMV), and intensive care unit (ICU) admission. We also considered the in-hospital and 30-day mortality. Data were grouped by smoking habit (non-, former-, and current-smokers) and the presence of COPD. Current smokers were younger, had fewer comorbidities, and fewer previous pneumonia episodes. CRP levels were higher in current smokers than in other groups. Current smokers had a higher risk of pleural complications independent of CRP levels, the presence of pleuritic pain, and a higher platelet count. Current smokers more often required IMV and ICU admission. Current smokers have a greater inflammatory response and are at increased risk of pleural complications.
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影响因子：
10
作者：
Menendez, R.;Cavalcanti, M.;Torres, A.
通讯作者：
Torres, A.
影响因子：
24.3
作者：
Gutierrez, P.;Closae, D.;Torres, A.
通讯作者：
Torres, A.
影响因子：
14.2
作者：
Garau, J.;Baquero, F.;Dal-Re, R.
通讯作者：
Dal-Re, R.
影响因子：
158.5
作者：
Fine, MJ;Auble, TE;Kapoor, WN
通讯作者：
Kapoor, WN
DOI：
10.1152/ajplung.00242.2015
发表时间：
2016-03-15
影响因子：
4.9
作者：
Gaydos, Jeanette;McNally, Alicia;Burnham, Ellen L.
通讯作者：
Burnham, Ellen L.