Guest editorial: Hematopoietic stem cells.
Guest editorial: Hematopoietic stem cells.
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客座社论：造血干细胞。
DOI：
10.1007/s12185-017-2267-4
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Nakajima H
中科院分区：
文献类型：
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作者：
Kunimoto H;Nakajima H.;Nakajima H
接受日期：2017年5月23日/在线发表日期：2017年5月29日©日本血液学会2017年用于HSC的能量供应。Takubo博士是第一个提出低氧状态下HSC代谢调节的分子机制的人，他将从低氧驱动的分子机制、脂肪酸代谢、氨基酸依赖性和核酸相关途径等方面总结目前对HSC代谢的理解。HSC小生境是HSC调节的细胞外因子的主要来源，已经进行了十多年的深入研究。HSC生态位提供多种因子维持HSC的静止状态及其自我更新和分化成多个谱系的能力，从而协调HSC及其后代的增殖和分化。骨髓内表面的成骨细胞是HSC龛的主要组成部分。然而，后来的研究揭示了各种细胞类型，包括血管周围细胞，窦周基质细胞[如CXCL 12丰富的网状（CAR）细胞，表达巢蛋白的基质细胞]，动脉周围基质细胞也是关键的生态位组分。Asada和Frenette在综述中总结了目前对HSC生态位的理解，其中他们描述了BM中由各种生态位细胞构成的复杂网络环境。
Accepted: 23 May 2017/Published online: 29 May 2017© The Japanese Society of Hematology 2017 utilized to supply energy in HSCs. Dr. Takubo was one of the first to show the molecular mechanism for metabolic regulation of HSC under hypoxic state, and he will summarize current understanding of HSC metabolism in view of hypoxia-driven molecular machinery, fatty acid metabolism, amino acid dependence, and nucleic acid-related pathways.HSC niche is a major source of extracellular factors for HSC regulation and has been under intense investigation for more than a decade. HSC niche supplies a variety of factors maintaining HSC quiescence and their capacities to self-renew and differentiate into multiple lineages, thereby orchestrates proliferation and differentiation of HSCs as well as their progenies. Osteoblasts lining on endosteal surface of the BM was first shown as a major component of HSC niche. However, later studies revealed various cell types including peri-vascular cells, peri-sinusoidal stromal cells [such as CXCL12-abundant reticular (CAR) cells, nestin-expressing stromal cells], peri-arteriolar stromal cells are also critical niche components. Current understanding of HSC niche is summarized in the review by Asada and Frenette, in which they describe a milieu of complex networks constituted by various niche cells in the BM.