Studies in the (+)-morphinan series. 4. A markedly improved synthesis of (+)-morphine
Studies in the (+)-morphinan series. 4. A markedly improved synthesis of (+)-morphine
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DOI：
10.1021/jo00401a038
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发表时间：
1978-03
影响因子：
3.6
通讯作者：
I. Iijima;J. Minamikawa;A. Jacobson;K. Rice
中科院分区：
文献类型：
--
作者：
I. Iijima;J. Minamikawa;A. Jacobson;K. Rice
Goto的组。4a~ c为了更清楚地定义吗啡与阿片受体的相互作用，我们想要制备大量的非天然对映体10和它的几个同系物。我们现在总结了我们的结果，基本上遵循了Goto的原始方案，4a~ c，但它实现了新的反应和其他人的发现，特别是Rapoport等人的发现。只有在我们开始我们的项目之后，Rapoport在自然（-）系列中的结果才可用。（+）-吗啡的总产量增加了十倍（10），先前由
Goto’s group. 4a~ c To define morphine’s interaction with opiate receptors more clearly, 5 we wanted to prepare large quantities of unnatural enantiomer 10 and several of its congeners. We now summarize our results that followed, in principal, Goto’s original scheme, 4a~ c but which implemented novel reactions and the findingsof others, especially those of Rapoport et al. 6 Rapoport’s results in the natural (—) series became available only after we had started our project. A tenfold increase in the overall yield of (+)-morphine (10), previously reported by