Differences in EEG harmonic driving responses to photic stimulation between normal aging and Alzheimer's disease
Differences in EEG harmonic driving responses to photic stimulation between normal aging and Alzheimer's disease
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DOI：
10.1177/155005940203300208
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发表时间：
2002-04-01
期刊：
影响因子：
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通讯作者：
Koshino, Y
中科院分区：
文献类型：
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作者：
Kikuchi, M;Wada, Y;Koshino, Y
为了研究阿尔茨海默病（AD）是大脑老化的最终结果还是其他机制的结果，我们分析了年轻受试者、非痴呆老年受试者和AD患者的脑电图，这些脑电图显示了对光刺激（PS）的谐波反应的绝对功率。在静息状态下，AD患者的绝对功率通常低于年轻和老年受试者，在10 Hz和20 Hz下存在显著差异。PS期间记录的EEG分析表明，老年受试者通常表现出比年轻受试者和AD患者更大的绝对功率。这些结果表明，AD患者的刺激相关的脑激活失败，并提供了进一步的证据，正常老化和AD采用不同的机制，在PS功能组织。
In order to investigate whether Alzheimer's disease (AD) is the end result of aging of the brain or the result of some other mechanism, we analyzed EEGs showing the absolute power of harmonic responses to photic stimulation (PS) in younger subjects, non-demented elderly subjects and AD patients. At rest, the AD patients generally showed less absolute power than the younger and elderly subjects, with significant differences found at 10Hz and 20Hz. Analysis of EEGs recorded during PS indicated that the elderly subjects generally demonstrated more absolute power than the younger subjects and AD patients. These findings suggest a failure of stimulation-related brain activation in AD patients, and provide further evidence that normal aging and AD employ different mechanisms for functional organization during PS.