Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice
Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice
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DOI：
10.1016/s1567-5769(02)00078-4
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发表时间：
2002-07-01
影响因子：
5.6
通讯作者：
Czlonkowska, A
中科院分区：
文献类型：
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作者：
Kurkowska-Jastrzebska, I;Babiuch, M;Czlonkowska, A
抗炎剂被假定在治疗神经退行性疾病中是有效的。在本研究中，我们发现吲哚美辛（IND）在1 mg/kg剂量下对帕金森病小鼠模型中的神经元保护免受1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）引起的毒性损伤。IND还减少了损伤区域的小胶质细胞活化和淋巴细胞浸润。这些观察结果表明，IND的抗炎特性可能在该模型中的神经元保护中发挥作用。然而，减少炎症反应可能继发于较少的神经元损伤。
The anti-inflammatory agents are postulated to be effective in treating neurodegenerative disorders. in this study, we showed that indomethacin (IND) in the dose of 1 mg/kg protected neurons against toxic damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice model of Parkinson's disease. IND also diminished microglial activation and lymphocytic infiltration in the injured areas. These observations suggest that anti-inflammatory properties of IND may play a role in the neuron's protection in this model. However, diminished inflammatory reaction may be secondary to less neuronal damage.