THE INVESTIGATION OF ALZHEIMERS-DISEASE WITH SINGLE PHOTON-EMISSION TOMOGRAPHY
THE INVESTIGATION OF ALZHEIMERS-DISEASE WITH SINGLE PHOTON-EMISSION TOMOGRAPHY
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DOI：
10.1136/jnnp.52.2.248
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发表时间：
1989-02-01
影响因子：
11
通讯作者：
LEVY, R
中科院分区：
文献类型：
--
作者：
BURNS, A;PHILPOT, MP;LEVY, R
使用锝 - 99m六甲基丙二胺肟和单光子发射断层扫描对20名符合阿尔茨海默病（AD）标准临床诊断标准的患者以及6名年龄匹配的正常对照者进行了研究。与对照组相比，AD患者在颞叶和顶叶后部的局部脑血流（rCBF）较低。伴有失用症和失语症的AD患者在颞叶外侧和顶叶后部的rCBF比无这些症状的AD患者更低。在AD组内，神经心理学测试与rCBF之间存在相关性：失用症与顶叶后部活动相关，记忆与左颞叶活动相关，语言与整个左半球的活动相关。
Twenty patients satisfying standard clinical criteria for Alzheimer''s disease (AD) and six age-matched normal controls were studied using 99mTc hexamethyl-propyleneamine oxime and single photon emission tomography. The AD patients had lower regional cerebral blood flow (rCBF) in the temporal and posterior parietal lobes compared to controls. AD patients with apraxia and aphasia had lower rCBF in the lateral temporal and posterior parietal lobes than AD patients without these features. Within the AD group, correlations were found between neuropsychological tests and rCBF: praxis correlated with posterior parietal activity, memory with left temporal lobe activity and language with activity throughout the left hemisphere.