Polymorphism p53 codon-72 and invasive cervical cancer: a metaanalysis
Polymorphism p53 codon-72 and invasive cervical cancer: a metaanalysis
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DOI：
10.1016/j.ijgo.2003.08.017
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发表时间：
2004-06-01
影响因子：
3.8
通讯作者：
Ji, SS
中科院分区：
文献类型：
--
作者：
Jee, SH;Won, SY;Ji, SS
目的：尽管已有研究报道P53基因第72位密码子上的精氨酸异构体增加了浸润性宫颈癌的易感性，但这些数据仍然存在争议。这项研究的目的是对这种关系的证据进行量化总结。方法：应用计算机检索MEDLINE 2002年12月前发表的文献、文献综述和专家咨询。37项研究符合纳入标准。样本大小、研究设计、Hardy-Weinberg平衡和基因决定方法的信息由两位评价者使用标准化方案提取。用Mantel-Haenzel方法估计P53基因与浸润性宫颈癌的总体优势比(OR)。结果：纯合子突变(arg/arg)与杂合子突变(arg/Pro)相比，患宫颈癌的OR值(95%可信区间)为1.2(1.1~1.3，P=0.001)。按细胞类型分类，精氨酸/精氨酸组与精氨酸/精氨酸组比较，腺癌的OR值差异有统计学意义(1.71.1~2.6P=0.024)，而鳞癌的OR值无统计学意义(1.1.0.9~1.2，P=0.960)。与Arg/Pro相比，Arg/Arg携带者在HPV16型中的优势比有统计学意义(1，5，1.2~2.0，P=0.002)。结论：总体而言，p53基因与浸润性宫颈癌风险增加有关。然而，风险因国家、细胞和HPV类型而异。(C)2003年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objectives: Although some studies have reported that the arginine isoform on codon 72 of p53 increases the susceptibility to invasive cervical cancer, such data remain controversial. The objective of this study was to quantitatively summarize the evidence for such a relationship. Methods: Our data sources consisted of a MEDLINE search of the literature published before December 2002, bibliography review, and expert consultation. Thirty-seven studies met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, and method of genotype determination was abstracted by two reviewers using a standardized protocol. The overall odds ratio (OR) of the p53 gene on invasive cervical cancer was estimated using the Mantel-Haenzel method. Results: The overall OR (95% confidence interval) for cervical cancer among those with the homozygous mutant (Arg/Arg) was 1.2 (1.1-1.3, P = 0.001) compared with those with the heterozygous mutant (Arg/Pro). By a cellular type of cervical cancer, the overall OR among those with Arg/Arg was statistically significant in adenocarcinomas (1.7, 1.1-2.6, P = 0.024), but not in squamous cell carcinomas (1.1, 0.9-1.2, P = 0.960), compared with Pro/Pro. Compared with Arg/ Pro, the OR among those with Arg/Arg was statistically significant in HPV types 16 (1,5, 1.2-2.0, P = 0.002). Conclusions: Overall, the p53 gene was associated with increased risk for invasive cervical cancer. However, the risk varied by country, cellular, and HPV type. (C) 2003 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.