Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.
Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.
复制标题
健康受试者和水肿患者的免疫反应性心房钠尿因子的血浆水平。
DOI：
10.1172/jci112154
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Grekin,RJ
中科院分区：
文献类型：
--
作者：
Shenker,Y;Sider,RS;Ostafin,EA;Grekin,RJ
心房利钠因子（ANF），最近测序的心脏肽，已被证明有强大的利钠，利尿，血管舒张作用，在几个物种。我们已经开发了一种放射免疫测定法来测量人血浆中免疫反应性ANF的水平。在健康志愿者中，低钠饮食的血浆ANF水平为9.8 +/- 1.4 pmol/L，高钠饮食的血浆ANF水平增加到21.9 +/- 3.0。心钠素水平与尿钠呈正相关，与血浆肾素活性和血浆醛固酮水平呈负相关。充血性心力衰竭导致明显水肿的患者血浆心钠素水平比正常高5倍（P <0.05），而肝硬化和水肿患者的水平与正常无差异。这些结果表明，心钠素在适应增加钠摄入中起重要作用。
Atrial natriuretic factor (ANF), a recently sequenced cardiac peptide, has been shown to have potent natriuretic, diuretic, and vasodilating effects in several species. We have developed a radioimmunoassay to measure the levels of immunoreactive ANF in human plasma. Plasma levels of ANF in healthy volunteers on a low sodium diet were 9.8 +/- 1.4 pmol/liter and increased to 21.9 +/- 3.0 on a high sodium diet. The levels of atrial natriuretic factor correlated directly with urinary sodium and inversely with plasma renin activity and plasma aldosterone levels. Patients with marked edema due to congestive heart failure had plasma levels of atrial natriuretic factor five times higher than normal (P less than 0.05), whereas patients with cirrhosis and edema had levels that were not different from normal. These results suggest that atrial natriuretic factor plays an important role in the adaptation to increased sodium intake.