Morphometry analysis of basal ganglia structures in children with obstructive sleep apnea
Morphometry analysis of basal ganglia structures in children with obstructive sleep apnea
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DOI：
10.3233/xst-16171
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Wang, Defeng
中科院分区：
文献类型：
--
作者：
Lv, Jian;Shi, Lin;Wang, Defeng
背景：阻塞性睡眠呼吸暂停（OSA）影响成人和儿童，可能由不同脑区的缺陷介导。脑结构改变与OSA综合征之间的联系在成人患者中已有报道，但与OSA儿童相关的证据仍然有限。目的：本研究旨在研究OSA儿童脑结构的改变，重点是基底节结构。我们招募了25名OSA儿童（年龄为10.3 +/- 1.5岁）和30名健康儿童（年龄为10.1 +/- 1.8岁）进行T1加权脑MRI，并对其大脑进行自动分割。结果：OSA组和对照组的左侧丘脑和左侧苍白球的形态计量学改变存在差异。与对照组相比，OSA组左侧丘脑腹后核和内侧背核明显萎缩，左侧苍白球内外段均出现局部扩张.结论：儿童OSA综合征与丘脑结构缺陷有关，这与成人OSA的研究结果一致.此外，本研究提供了新的视野，以独特的模式苍白球的结构变化在儿童OSA相比，成人OSA。
BACKGROUND: Obstructive sleep apnea (OSA) affects both adults and children, likely mediated by the deficits of various brain regions. The association between structural alterations in the brain and OSA syndrome have been reported in adult patients, but the corresponding evidence for OSA children is still limited.OBJECTIVE: The proposed study aimed to investigate the structural alterations in the brain of children with OSA, with focus on basal ganglia structures.METHODS: We recruited 25 OSA children (aged 10.3 +/- 1.5 years) and 30 healthy children (aged 10.1 +/- 1.8 years) with T1-weighted brain MRI and performed automatic segmentation of their brains. The shape alterations of the basal ganglia structures for OSA syndrome was determined by comparison of the OSA group and control group with surface-based shape analysis.RESULTS: Differences in the morphometry of the left thalamus and the left pallidum were found between the OSA group and control group. Compared to the control group, the OSA group presented significant atrophy in the ventral posterior nucleus and the medial dorsal nucleus of the left thalamus, while regional dilation was found in both the internal and external segments of the left pallidum.CONCLUSION: These findings identified the association between the structural deficits of the thalamus and OSA syndrome in children, whichwas consistent with the existing findings in OSA adults. In addition, the present study provided newinsights to the distinctive pattern of structural changes of the pallidum in pediatric OSA when compared to adult OSA.