Repeatability of regional pulmonary functional metrics of Hyperpolarized 129Xe dissolved-phase MRI
Repeatability of regional pulmonary functional metrics of Hyperpolarized 129Xe dissolved-phase MRI
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DOI：
10.1002/jmri.26745
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发表时间：
2019-10-01
影响因子：
4.4
通讯作者：
Fain, Sean B.
中科院分区：
文献类型：
--
作者：
Hahn, Andrew D.;Kammerman, Jeff;Fain, Sean B.
超极化（129）氙核磁共振（HP Xe-129）越来越多地用于研究肺功能。HP Xe-129在肺组织、血浆（屏障）和红细胞（RBC）中的溶解度，具有独特的化学位移，使气体交换和微观结构肺生理的潜在成像生物标志物的光谱成像成为可能。目的量化溶相Xe-129成像得出的屏障：气体、RBC：气体和RBC：屏障比率的全球平均和区域重复性，以及它们对访视期间肺充气式变化的依赖。前瞻性研究类型。人口14名健康志愿者。1名受试者无法完成研究，导致13名受试者进行分析（8名女性，5名男性，年龄24-69岁，53.8±13.9）。场强1.5T。在两个不同的时间点，随访间隔约为1个月，使用三维径向1点Dixon方法对受试者进行成像，以分离Barrier和RBC成分信号。RBC:Gas， Barrier:Gas和RBC:Barrier测量在不同时间和肺功能试验（pft）中进行比较。采用Bland-Altman图、可重复性系数、变异系数（CV）和类内相关系数（ICCs）对重复性进行量化。影像学指标对PFTs和肺体积的依赖性分别采用Spearman和Pearson相关系数进行评估。组内相关采用f检验，Spearman相关和回归采用t检验。结果平均RBC:Gas、Barrier:Gas和RBC:Barrier的cv分别为19.2%、20.0%和11.5%，具有显著的ICCs，分别为0.78、0.79和0.92。访间RBC:Barrier差异与DLCO差异显著相关（r = 0.93, P = 0.007）。两组间肺容量差异、RBC:Gas平均值（r = -0.73, P = 0.005）和Barrier:Gas平均值（r = -0.69, P = 0.009）显著相关。三种常用的基于Xe-129 mri的气体交换测量具有良好的重复性，特别是屏障：红细胞比率，它不依赖于肺膨胀量，与DLCO的访间变化密切相关。技术功效：1期。的原因。成像2019;50:1182 - 1190。
Background MRI of hyperpolarized (129)Xenon (HP Xe-129) is increasingly utilized for investigating pulmonary function. The solubility of HP Xe-129 in lung tissue, blood plasma (Barrier), and red blood cells (RBC), with unique chemical shifts, enables spectroscopic imaging of potential imaging biomarkers of gas exchange and microstructural pulmonary physiology. Purpose To quantify global average and regional repeatability of Barrier:gas, RBC:gas, and RBC:Barrier ratios derived from dissolved-phase Xe-129 imaging and their dependence on intervisit changes in lung inflation volume. Study Type Prospective. Population Fourteen healthy volunteers. One subject was unable to complete the study resulting in 13 subjects for analysis (eight female, five male, ages 24-69, 53.8 +/- 13.9). Field Strength 1.5T. Assessment Subjects were imaged using a 3D radial 1-point Dixon method to separate Barrier and RBC component signals, at two different timepoints, with similar to 1 month between visits. RBC:Gas, Barrier:Gas, and RBC:Barrier measures were compared across time and with pulmonary function tests (PFTs). Statistical Tests Repeatablilty was quantified using Bland-Altman plots, coefficient of repeatability, coefficient of variation (CV), and intraclass correlation coefficients (ICCs). Dependence of imaging measures on PFTs and lung volume was evaluated using Spearman and Pearson correlation coefficients, respectively. Statistical significance was determined by F-test for intraclass correlations, and t-test for Spearman correlations and regression. Results Mean RBC:Gas, Barrier:Gas, and RBC:Barrier had CVs of 19.2%, 20.0%, and 11.5%, respectively, and had significant ICCs, equal to 0.78, 0.79, and 0.92, respectively. Intervisit differences in RBC:Barrier were significantly correlated with intervisit differences in DLCO (r = 0.93, P = 0.007). Significant correlations with intervisit lung volume differences and intervisit differences in mean RBC:Gas (r = -0.73, P = 0.005) and Barrier:Gas (r = -0.69, P = 0.009) were found. Data Conclusion Three commonly used Xe-129 MRI-based measures of gas-exchange show good repeatability, particularly the Barrier:RBC ratio, which did not depend on lung inflation volume and was strongly associated with intervisit changes in DLCO. Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:1182-1190.