Longitudinal research on the bidirectional association between depression and arthritis
Longitudinal research on the bidirectional association between depression and arthritis
复制标题
抑郁症与关节炎之间双向关联的纵向研究。
DOI：
10.1007/s00127-020-01994-7
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发表时间：
2020-11-22
影响因子：
4.4
通讯作者：
Wu, Ying
中科院分区：
文献类型：
--
作者：
Ke, Chaofu;Qiao, Yanan;Wu, Ying
目的 评估抑郁症与关节炎之间相互关系的研究有限，且结果并不一致。本研究旨在探讨中国中老年人中抑郁症与关节炎的双向关系。方法 研究对象来自中国健康与养老追踪调查（CHARLS）中年龄≥45岁的参与者。在第一阶段，我们评估了基线抑郁症与随访时关节炎发病的关联。在第二阶段，我们研究关节炎的发病是否能预测未来抑郁症的发生。分别在第一阶段和第二阶段进行逻辑回归分析，以估计优势比（OR）和置信区间（CI）。结果 在第一阶段，抑郁症组中有24.3%（679/2794）的人出现新发关节炎病例，非抑郁症组这一比例为15.4%（1000/6482）。与无抑郁症者相比，抑郁症患者患关节炎的风险显著更高（OR：1.56，95%CI 1.37 - 1.79）。在第二阶段，关节炎组中有39.7%（973/2453）的受试者出现抑郁症状，非关节炎组这一比例为26.7%（1667/6236）。关节炎组患抑郁症的校正后OR（95%CI）为1.64（1.45 - 1.86），高于非关节炎组。根据性别、年龄、家庭收入、居住地、体重指数、吸烟和饮酒情况进行的亚组分析显示，各亚组的关联一致。结论 抑郁症的发作增加了患关节炎的风险；此外，基线时患有关节炎可预测中国中老年人群未来发生抑郁症。
Purpose Studies evaluating the mutual relation between depression and arthritis have been limited and yielded inconsistent results. The aim of this study was to investigate the bidirectional relationship between depression and arthritis in a middle-aged and elderly Chinese population. Methods Participants >= 45 years of age were included from the China Health and Retirement Longitudinal Study (CHARLS). In stage I, we assessed the association of baseline depression with follow-up arthritis. In stage II, we examined whether the onset of arthritis predicted future depression. Logistic regression analyses were conducted to estimate the odds ratios (ORs) and confidence intervals (CIs) in stage I and stage II, respectively. Results In stage I, 24.3% (679/2794) of the depression group and 15.4% (1000/6482) of the non-depression group developed new arthritis cases. Compared with non-depression individuals, the risk of developing arthritis in depression patients was significantly higher (OR: 1.56, 95% CI 1.37-1.79). In stage II, 39.7% (973/2453) subjects in the arthritis group and 26.7% (1667/6236) subjects in the non-arthritis group developed depressive symptoms. The adjusted OR (95% CI) for depression in the arthritis group was 1.64 (1.45-1.86) times higher than that in the non-arthritis group. In the subgroup analyses according to sex, age, household income, residence, body mass index, smoking and drinking, all sub-groups yielded consistent associations. Conclusion The onset of depression increased the risk of incident arthritis; in addition, baseline arthritis predicted future depression in middle-aged and elderly Chinese adults.