Mechanisms of action of intravenous immunoglobulin
Mechanisms of action of intravenous immunoglobulin
复制标题
DOI：
10.1016/j.transci.2016.12.017
复制
发表时间：
2017-02-01
影响因子：
1.9
通讯作者：
Mouthon, Luc
中科院分区：
文献类型：
--
作者：
Chaigne, Benjamin;Mouthon, Luc
借2016年4月在巴黎召开的“世界单采协会/Societe Francaise d'Hemapherese”会议之机，本文对目前关于静脉注射免疫球蛋白作用机制的认识进行综述。免疫球蛋白是一种血浆衍生药物，最初被用作抗体缺乏患者的替代疗法。自 1980 年以来，它们还因其抗炎和免疫调节功效而被用于治疗自身免疫性疾病。在此，我们先回顾其生产和成分的要求，然后特别关注其作用机制，包括替代和免疫调节。 (c) 2017 Elsevier Ltd. 保留所有权利。
Taking advantage of the "World Apheresis Association/Societe Francaise d'Hemapherese" meeting held in Paris in April 2016, this article reviews the current knowledge on the mechanisms of action of intravenous immunoglobulins. Immunoglobulins are a plasma-derived drug, which have been initially used as a replacement therapy for patients with antibody deficiency. Since 1980 they have also been used for their anti-inflammatory and immunomodulating efficacy in auto-immune diseases. Herein, we review the requirements for their production and composition before giving a specific attention to their mechanisms of action including substitution and immunomodulation. (c) 2017 Elsevier Ltd. All rights reserved.