BACTERIAL CYTOTOXICITY OF THE SILVER NANOPARTICLE RELATED TO PHYSICOCHEMICAL METRICS AND AGGLOMERATION PROPERTIES
BACTERIAL CYTOTOXICITY OF THE SILVER NANOPARTICLE RELATED TO PHYSICOCHEMICAL METRICS AND AGGLOMERATION PROPERTIES
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DOI：
10.1002/etc.278
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发表时间：
2010-10-01
影响因子：
4.1
通讯作者：
Yi, Jongheop
中科院分区：
文献类型：
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作者：
Bae, Eunjoo;Park, Hee-Jin;Yi, Jongheop
银颗粒由于其积极作用而用于各种消费品中，所述积极作用包括杀菌和抗菌性质。然而，据报道，银纳米颗粒（AgNPs）对各种细胞具有强烈的急性毒性作用。因此，AgNP的细胞毒性进行了研究，使用大肠杆菌作为模式生物，从三个关键指标（离子比，大小和团聚）的立场是最相关的物理化学性质。研究结果表明，细胞毒性被AgNPs的团聚所抑制。毒性敏感性大小顺序为：总银浓度>离子比>粒径，其大小顺序与团聚程度呈负相关。Environ.毒理学. 2010;29：2154-2160。(C)2010年SETAC
Silver particles are used in various consumer products due to their positive effects, which include sterilization and antibacterial properties. However, it has been reported that silver nanoparticles (AgNPs) have strongly acute toxic effects on various cells. Therefore, the cytotoxicity of AgNPs was investigated, using Escherichia coli as a model organism, from the standpoint of three key metrics (ionic ratio, size, and agglomeration) that are the most relevant physicochemical properties. The findings indicated that cytotoxicity is depressed by the agglomeration of AgNPs. The order of toxic sensitivity was as follows: total Ag concentration > ionic ratio > size, the order of which was inversely related to the extent of agglomeration. Environ. Toxicol. Chem. 2010;29:2154-2160. (C) 2010 SETAC