Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer.
Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer.
复制标题
microRNA-205 的过度表达可预测淋巴结转移并表明子宫内膜癌的不良预后
DOI：
10.3892/ol.2016.5262
复制
发表时间：
2016-12
期刊：
影响因子：
2.9
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Ma YJ;Ha CF;Bai ZM;Li HN;Xiong Y;Jiang J
作为手术分期系统的一个组成部分，子宫内膜癌（EC）患者的淋巴结切除术仍然存在争议，特别是在临床I期疾病，不仅包括低风险，但也包括高风险亚组。为了最大限度地提高淋巴结切除术对高危患者的治疗效果，使其可能从中获得生存获益，同时最大限度地减少其对低危患者的不利影响，术前淋巴结转移风险分层是必要的。最近一直有报道子宫内膜癌中microRNA-205（miR-205）的上调，并发现其与生存不良相关。本研究旨在探讨miR-205在EC刮除样本中的过表达是否可以识别手术前淋巴结转移的高危患者，并验证miR-205作为EC预后标志物的作用。对EC患者的刮宫和子宫切除标本进行miR-205的相对定量检测。对所有EC患者和临床I期疾病患者进行基于miR-205表达的淋巴结转移预测，以及刮除样品中的肿瘤类型和分级。并进行生存分析。观察到miR-205在EC的刮宫和子宫切除样品中相对于正常对照显著且一致地升高。此外，miR-205的过表达可以高准确性地预测淋巴结转移，并且再次被揭示与EC的不良预后相关。需要前瞻性和多中心研究来进一步阐明miR-205作为EC淋巴结转移风险分层的有希望的预测因子的价值。
As an integral component of the surgical staging system, lymphadenectomy for patients with endometrial cancer (EC) remains controversial, particularly in clinical stage I disease that includes not only low-risk, but also high-risk subgroups. In order to maximize the therapeutic effect of lymph node excision for high-risk patients who can potentially obtain survival benefits from it while minimizing its reverse effects in low-risk patients, pre-operative risk stratification of lymph node metastasis is necessary. The upregulation of microRNA-205 (miR-205) in carcinoma of the endometrium has been consistently reported recently and has been found to correlate with poor survival. The current study aimed to investigate whether the overexpression of miR-205 in curettage samples of EC could identify patients who are at a high risk for lymph node metastasis prior to surgery and validate the role of miR-205 as a prognostic marker in EC. Relative quantification detection of miR-205 in curettage and hysterectomy specimens of patients with EC was performed. Prediction of lymph node metastasis based on miR-205 expression, as well as tumor type and grade in curettage samples, was performed for all EC patients and patients with clinical stage I disease. Moreover, survival analysis was conducted. It was observed that miR-205 was significantly and consistently elevated in the curettage and hysterectomy samples of EC relative to normal controls. Furthermore, the overexpression of miR-205 could predict lymph node metastasis with a high accuracy and was revealed again to be associated with a poor prognosis in EC. Prospective and multicentric studies are required to further clarify the value of miR-205 as a promising predictor to stratify risk for lymph node metastasis in EC.