SWALLOW-EVOKED ACTION-POTENTIALS IN VAGAL PREGANGLIONIC EFFERENTS
SWALLOW-EVOKED ACTION-POTENTIALS IN VAGAL PREGANGLIONIC EFFERENTS
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DOI：
10.1152/jn.1984.52.6.1169
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
GOYAL, RK
中科院分区：
文献类型：
--
作者：
GIDDA, JS;GOYAL, RK
用单纤维记录技术研究了负鼠麻醉后神经节前迷走神经纤维的吞咽诱发电位。咽触觉刺激或电刺激喉上神经（SLN）中端切口均可诱发吞咽。用下颌舌骨肌电图和食管运动记录吞咽活动。对66种纤维进行了吞咽诱发动作电位的研究。不同纤维诱发反应的潜伏期（从髓舌骨骨活动开始）从100 ms到5 s不等。诱发反应的放电速率为每脉冲3-8个动作电位。每次爆发持续1.1 .+-。0.02 (SE) s.吞咽诱发放电的短潜伏期和长潜伏期纤维潜伏期与食管平滑肌反应的关系表明，短潜伏期放电可能与初始抑制潜伏期有关，而长潜伏期纤维潜伏期可能与蠕动收缩潜伏期有关。基于这些时间关系，迷走神经传出纤维表现出吞咽诱发的短潜伏期放电，与壁内抑制性神经元接触。它们可能介导食道体的吞咽抑制、下食道括约肌的松弛和胃底的接受性松弛。显示晚期放电的纤维与壁内兴奋性神经元接触并参与其顺序激活。这种双重激活途径可能是生理性食管蠕动的原因。
Swallow-evoked potentials in the preganglionic vagal fibers were studied using the single-fiber recording technique in anesthetized opossums. Swallows were evoked by tactile pharyngeal stimulation or electrical stimulation of the cut central end of the superior laryngeal nerve (SLN). Swallowing activity was recorded by the mylohyoid electromyogram and esophageal motility. Sixty-six fibers were studied in which swallowing evoked action potentials. The latencies (from the onset of mylohyoid activity) of evoked responses in different fibers varied from 100 ms to 5 s. The discharge rate of the evoked response was 3-8 action potentials per burst. Each burst lasted 1.1 .+-. 0.02 (SE) s. The relationship between the latencies of swallow-evoked discharges in the short- and long-latency fibers and the esophageal smooth muscle responses suggested that the short-latency discharges may correlate with the latency of initial inhibition, and the long-latency fibers may correlate with latencies of peristaltic contractions. Based on these temporal relationships, vagal efferent fibers showing swallow-evoked, short-latency discharges make contact with intramural inhibitory neurons. They may mediate deglutitive inhibition in the body of the esophagus, relaxation of the lower esophageal sphincter, and receptive relaxation of the fundus of the stomach. The fibers showing late discharges make contact with intramural excitatory neurons and participate in their sequential activation. This dual pathway of activation may be responsible for physiological esophageal peristalsis.