Randomized Clinical Trial on Sodium Fluoride with Tricalcium Phosphate.
Randomized Clinical Trial on Sodium Fluoride with Tricalcium Phosphate.
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DOI：
10.1177/0022034520952031
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发表时间：
2021-01
影响因子：
7.6
通讯作者：
Chu CH
中科院分区：
文献类型：
--
作者：
Chen KJ;Gao SS;Duangthip D;Lo ECM;Chu CH
这项为期24个月的随机对照试验是基于双盲平行设计，比较了2种氟化物应用方案在阻止乳牙牙本质龋方面的有效性。招募患有活动性牙本质龋的3岁儿童，并随机分配到2个治疗组。A组的儿童每半年接受一次25%硝酸银（AgNO 3）溶液的应用，然后在龋面上使用含有5%氟化钠（NaF）的市售保护漆。B组的儿童每半年使用一次25%AgNO3溶液，然后使用另一种含有5%NaF的市售清漆，其中含有功能化磷酸三钙（fTCP）。在探查时坚硬的龋齿表面被归类为被阻止。进行意向治疗分析和分层广义线性模型。基线时共招募了408名儿童，1，831个牙齿表面患有活动性牙本质龋，24个月后对356名儿童（87%），1，607个牙齿表面（88%）进行了评估。在24个月评价时，A组（无fTCP）和B组（有fTCP）每名儿童的平均（SD）阻龋牙面数量分别为1.8（2.2）和2.6（3.3）（P = 0.003）。牙面阻滞率A组为42%，B组为57%（P < 0.001）。分层广义线性模型的结果表明，方案B（与fTCP）有较高的预测概率（PP = 0.656），在阻止牙本质龋比方案A（无fTCP; PP = 0.500）时，龋损是在颊/舌面，是在前牙，有牙菌斑覆盖，并从低收入家庭的儿童（P = 0.046）。总之，与方案A相比，方案B（每半年施用25% AgNO 3溶液，然后每半年施用一次市售的5% NaF清漆（不含fTCP））在阻止乳牙牙的牙本质龋方面更有效（ClinicalTrials.gov NCT 03423797）。
This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Children in group A received a semiannual application of a 25% silver nitrate (AgNO3) solution followed by a commercially available varnish with 5% sodium fluoride (NaF) on the carious tooth surfaces. Children in group B received a semiannual application of a 25% AgNO3 solution followed by another commercially available varnish with 5% NaF containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard when probing were classified as arrested. Intention-to-treat analysis and a hierarchical generalized linear model were undertaken. A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline, and 356 children (87%) with 1,607 tooth surfaces (88%) were assessed after 24 mo. At the 24-mo evaluation, the mean (SD) number of arrested carious tooth surfaces per child were 1.8 (2.2) and 2.6 (3.3) for group A (without fTCP) and group B (with fTCP), respectively (P = 0.003). The arrest rates at the tooth surface level were 42% for group A and 57% for group B (P < 0.001). Results of the hierarchical generalized linear model indicated that protocol B (with fTCP) had a higher predicted probability (PP = 0.656) in arresting dentine caries than protocol A (without fTCP; PP = 0.500) when the carious lesions were on buccal/lingual surfaces, were on anterior teeth, had dental plaque coverage, and were in children from low-income families (P = 0.046). In conclusion, protocol B, which applied a 25% AgNO3 solution followed by a commercially available 5% NaF varnish with fTCP semiannually, is more effective in arresting dentine caries in primary teeth as compared with protocol A, which applied a 25% AgNO3 solution followed by another commercially available 5% NaF varnish without fTCP semiannually (ClinicalTrials.gov NCT03423797).
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影响因子：
--
作者：
Gupta SK
通讯作者：
Gupta SK
影响因子：
1.8
作者：
Barbosa Neves, Erick Tassio;Firmino, Ramon Targino;Granville-Garcia, Ana Flavia
通讯作者：
Granville-Garcia, Ana Flavia
影响因子：
2.2
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通讯作者：
Olivieri, A.
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作者：
Fung, M H T;Duangthip, D;Chu, C H
通讯作者：
Chu, C H
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Karlinsey, R L;Pfarrer, A M
通讯作者：
Pfarrer, A M