Remote ischemic conditioning: the enigmatic transfer of protection.
Remote ischemic conditioning: the enigmatic transfer of protection.
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DOI：
10.1093/cvr/cvw240
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发表时间：
2017
影响因子：
10.8
通讯作者：
G. Heusch
中科院分区：
文献类型：
--
作者：
G. Heusch
这篇社论引用了Basalay et al.，doi：10.1093/cvr/cvw 216的“胰高血糖素样肽-1（GLP-1）通过远程缺血调节介导心脏保护”。远程缺血预处理是对各种组织或器官的短暂非致死性缺血/再灌注的全身反应，其在一定距离内对许多靶组织或器官提供保护。这些靶器官，包括脑、心脏、肝、肺、肠、肾、骨骼肌和皮肤，对持续缺血/再灌注的抵抗力更强。1可在持续缺血之前（预）、期间（预）和之后（预处理）引发远程缺血预处理。外周刺激似乎涉及感觉神经纤维和/或血管切应力的激活，并且靶器官（特别是心脏）中的保护性信号转导与局部缺血预处理和后处理的保护性信号转导非常相似。然而，远距离缺血性条件反射最吸引人的特征是保护性信号在更远的距离上的传递。这种转移似乎在机械上涉及体液和神经通路，但在其细节上很大程度上是谜。1，2另一方面，正是这种保护从外周转移到中枢器官，如大脑，心脏和肾脏，吸引了潜在翻译的临床兴趣。许多研究表明，接受心血管手术的患者...
This editorial refers to ‘Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning’ by Basalay et al. , doi: 10.1093/cvr/cvw216. Remote ischemic conditioning is the systemic response to brief non-lethal ischemia/reperfusion in various tissues or organs which provides protection to a number of target tissues or organs over a distance. These target organs, including brain, heart, liver, lungs, intestine, kidneys, skeletal muscle, and skin, are then more resistant to sustained ischemia/reperfusion.1 Remote ischemic conditioning can be elicited prior (pre-), during (per-) and following (post-conditioning) the sustained ischemia. The peripheral stimulus appears to involve the activation of sensory nerve fibers and/or vascular shear stress, and the protective signal transduction in the target organs, notably in the heart, is very similar to that of local ischemic pre- and post-conditioning. The most fascinating feature of remote ischemic conditioning, however, is the transfer of a protective signal over a larger distance. This transfer appears to mechanistically involve both humoral and neuronal pathways but is largely enigmatic in its details.1,2 On the other hand, just this transfer of protection from the periphery to central organs such as brain, heart, and kidneys has attracted clinical interest for potential translation. A number of studies in patients undergoing cardiovascular surgery have …