Interleukin-1 receptor antagonist
Interleukin-1 receptor antagonist
复制标题
DOI：
10.1016/s0889-857x(05)70029-6
复制
发表时间：
1998-08-01
影响因子：
2.3
通讯作者：
Cunnane, G
中科院分区：
文献类型：
--
作者：
Bresnihan, B;Cunnane, G
IL-1基因家族有三个成员：IL-1 α、IL-1 β和IL-1ra。IL-1 α和IL-1 β都是具有许多促炎作用的拮抗分子。IL-1ra是一种拮抗剂分子，可通过特异性阻断靶效应细胞上的IL-1受体来抑制IL-1 α和IL-1 β的作用。IL-1 α和IL-1 β被认为是许多炎症性疾病发病机制中的关键细胞因子。在动物模型和RA中，抗il -1治疗已被证明可以改善关节炎，这表明IL-1ra可能是未来RA治疗的重要治疗选择。
There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra. IL-1 alpha and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells. IL-1 alpha and IL-1 beta are considered to be pivotal cytokines in the pathogenesis of many inflammatory diseases. Anti-IL-1 treatment has been shown to cause amelioration of arthritis in animal models and in RA, suggesting that IL-1ra may be an important therapeutic option in the future management of RA.