Follow-up of a Large Prospective Cohort in the United States Using Linkage With Multiple State Cancer Registries
Follow-up of a Large Prospective Cohort in the United States Using Linkage With Multiple State Cancer Registries
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DOI：
10.1093/aje/kwx129
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发表时间：
2017-10-01
影响因子：
5
通讯作者：
Patel, Alpa V.
中科院分区：
文献类型：
--
作者：
Jacobs, Eric J.;Briggs, Peter J.;Patel, Alpa V.
美国所有的州现在都有一个完善的癌症登记处。在多州队列研究中，与这些登记处联系可能是一种具有成本效益的癌症发病率随访方法。然而，在队列研究中，与当前国家登记处网络联系检测癌症诊断的敏感性并没有得到很好的记录。我们检查了来自23个州的39,368名男性和女性的登记联系的敏感性，这些人在2006-2009年期间参加了癌症预防研究-3队列，并有机会在2011年的问卷中自我报告癌症诊断。所有参与者都提供了姓名和出生日期，94%的人提供了完整的社会安全号码。在入组至2010年期间，通过自我报告确定并通过医疗记录验证的378例癌症诊断中，还通过与23个州癌症登记处的联系发现了338例（灵敏度为89%，95%置信区间（CI）： 86,92）。血液癌（69%,95% CI: 41,89）和黑色素瘤（70%,95% CI: 57,81）的敏感性较低。排除血液癌和黑色素瘤后，敏感性为94% （95% CI: 91,97）。我们的研究结果表明，在多州队列研究中，除了血液病癌症和黑色素瘤之外，与多个癌症登记处的联系可能是确定癌症事件的敏感方法。
All states in the United States now have a well-established cancer registry. Linkage with these registries may be a cost-effective method of follow-up for cancer incidence in multistate cohort studies. However, the sensitivity of linkage with the current network of state registries for detecting incident cancer diagnoses within cohort studies is not well-documented. We examined the sensitivity of registry linkage among 39,368 men and women from 23 states who enrolled in the Cancer Prevention Study-3 cohort during 2006-2009 and had the opportunity to self-report cancer diagnoses on a questionnaire in 2011. All participants provided name and birthdate, and 94% provided a complete social security number. Of 378 cancer diagnoses between enrollment and 2010 identified through self-report and verified with medical records, 338 were also detected by linkage with the 23 state cancer registries (sensitivity of 89%, 95% confidence interval (CI): 86, 92). Sensitivity was lower for hematologic cancers (69%, 95% CI: 41, 89) and melanoma (70%, 95% CI: 57, 81). After excluding hematologic cancers and melanoma, sensitivity was 94% (95% CI: 91, 97). Our results indicate that linkage with multiple cancer registries can be a sensitive method for ascertaining incident cancers, other than hematologic cancers and melanoma, in multistate cohort studies.