DNA repair capacity in healthy medical students during and after exam stress
DNA repair capacity in healthy medical students during and after exam stress
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DOI：
10.1023/a:1005503502992
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发表时间：
2000-12-01
影响因子：
3.1
通讯作者：
Wei, QY
中科院分区：
文献类型：
--
作者：
Cohen, L;Marshall, GD;Wei, QY
关于应激对免疫功能的影响已经有了广泛的研究，但是关于应激对DNA修复能力（DRC）的影响的研究很少，DNA修复能力是维持正常细胞周期的核心过程。在本研究中，我们评估了DRC在健康的医学生在高，低压力的时候。16名医学生在为期5天的考试期间的第三天进行了评估，然后再次3周国际米兰，假期后。在这两个时间点，参与者接受了简短的身体检查，抽取了静脉血，并完成了问卷调查，以确定主观压力水平。通过宿主细胞反应测定法评估DRC，所述宿主细胞反应测定法测量核苷酸切除修复能力。参与者报告说，考试期间的主观压力水平显着高于假期后。DRC也显着高于考试期间比假期后，这表明受试者的压力水平和DRC之间的正相关。结果进行了讨论，与以前的研究结果和癌症研究的影响。
There has been extensive research into the effects of stress on immune function but little on the effects of stress on DNA repair capacity (DRC), a process central to maintaining a normal cell cycle Defective DRC is one of the factors responsible for carcinogenesis. In the present study we assessed DRC in healthy medical students during times of high and low stress. Sixteen medical students were evaluated during the third day of a 5-day exam period and then again 3 weeks Inter, after vacation. At both time points, participants underwent a brief physical examination had venous blood drawn, and completed questionnaires to identify subjective stress levels. The DRC was assessed by the host-cell reaction assay, which measures nucleotide excision repair capacity. Participants reported significantly higher levels of subjective stress during the exam period than after vacation. DRC was also significantly higher during the exam period than after vacation, suggesting a positive association between subject stress levels and DRC. The results are discussed in relation to previous findings and implications for cancer research.