Integral lipids of hair and stratum corneum.
Integral lipids of hair and stratum corneum.
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头发和角质层的整体脂质。
DOI：
10.1007/978-3-0348-9223-0_7
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Wertz,PW
中科院分区：
文献类型：
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作者：
Wertz,PW
在过去的10年里，在羊毛和头发以及表皮角质层中都发现了共价结合的脂质。在头发中，脂肪酸，其中最丰富的是18-甲基糖酸，通过硫酯连接到角质层细胞外表面的蛋白质上。这种脂质层，即脂肪层或f层，被认为在决定头发和羊毛的表面特性方面具有重要意义。在表皮角质层中，共价附着的脂质已被确定为一种omega-羟基神经酰胺，由30至34个碳的omega-羟基酸酰胺与鞘氨醇碱相连。羟基神经酰胺分子通过酯键附着在角质包膜的外表面，并提供覆盖所有角质细胞外表面的单层。这种共价结合的脂质层或脂质包膜与游离脂质相互作用，并对细胞间隙中脂质层状结构的组织有重要影响。
Within the past 10 years, covalently bound lipids have been identified both in wool and hair and in epidermal stratum corneum. In hair, fatty acids, the most abundant of which is 18-methyleicosanoic acid, are attached via thioester linkages to protein at the outer surface of cuticle cells. This lipid layer, the fatty layer or F-layer, is thought to be of major significance in determining the surface properties of hair and wool. In epidermal stratum corneum, the covalently attached lipid has been identified as an omega-hydroxyceramide consisting of 30-through 34-carbon omega-hydroxyacids amide-linked to sphingosine bases. The hydroxyceramide molecules are attached to the outer surface of the cornified envelope through ester linkages, and provide a monolayer covering the outer surface of all corneocytes. This covalently bound lipid layer, or lipid envelope, interacts with free lipids and has a major influence on the organization of lipid lamellar structures in the intercellular space.