GLUCOSE-TRANSPORT INTO RAT SKELETAL-MUSCLE - INTERACTION BETWEEN EXERCISE AND INSULIN
GLUCOSE-TRANSPORT INTO RAT SKELETAL-MUSCLE - INTERACTION BETWEEN EXERCISE AND INSULIN
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DOI：
10.1152/jappl.1988.65.2.909
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发表时间：
1988-08-01
影响因子：
3.3
通讯作者：
HOLLOSZY, JO
中科院分区：
文献类型：
--
作者：
WALLBERGHENRIKSSON, H;CONSTABLE, SH;HOLLOSZY, JO
本研究旨在评价胰岛素对运动后骨骼肌糖转运的影响。在一次运动后30、60和180 min，测定了暴露于一系列胰岛素浓度后大鼠上滑车肌对3-O-甲基葡萄糖（3-MG）的渗透性。运动后30分钟和60分钟，运动和胰岛素对3-MG转运的影响在广泛的胰岛素浓度范围内是相加的，对胰岛素的敏感性或反应性没有增加。180分钟后，当66%的运动引起的糖转运增加已经消失，葡萄糖转运过程对胰岛素的反应性和敏感性都增加了。这些发现似乎与运动和胰岛素的作用导致哺乳动物骨骼肌中两个独立的葡萄糖转运蛋白库激活和/或易位到质膜中的假设是一致的。
This study was done to evaluate the effect of insulin on sugar transport into skeletal muscle after exercise. The permeability of rat epitrochlearis muscle to 3-O-methylglucose (3-MG) was measured after exposure to a range of insulin concentrations 30, 60, and 180 min after a bout of exercise. Thirty and 60 min after exercise, the effects of exercise and insulin on 3-MG transport were additive over a wide range of insulin concentrations, with no increase in sensitivity or responsiveness to insulin. After 180 min, when .apprx. 66% of the exercise-induced increase in sugar transport had worn off, both the responsiveness and sensitivity of the glucose transport process to insulin were increased. These findings appear compatible with the hypothesis that the actions of exercise and insulin result in activation and/or translocation into the plasma membrane of two separate pools of glucose transporters in mammalian skeletal muscle.