A meta-analysis of MSI frequency and race in colorectal cancer
A meta-analysis of MSI frequency and race in colorectal cancer
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DOI：
10.18632/oncotarget.8945
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发表时间：
2016-06-07
期刊：
影响因子：
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通讯作者：
Nouraie, Mehdi
中科院分区：
文献类型：
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作者：
Ashktorab, Hassan;Ahuja, Sadhna;Nouraie, Mehdi
目得：非裔美国人（AA）是结直肠癌（CRC）的高危人群，一些研究报道其微卫星不稳定性（MSI）发生率较高，而另一些研究报道其MSI发生率较低。目的：通过Meta分析，确定和评价种族和临床因素与MSI发生率的关系。在不同的文献数据库中检索了15，105项研究（1997-2015）中的22项研究，使用关键词“结直肠癌，微卫星不稳定性，非洲裔美国人，高加索人和西班牙裔美国人”。我们使用随机效应荟萃分析来计算所有研究以及非洲裔美国人和高加索人样本中的MSI频率。结果：CRCs的MSI发生率为17%（95% CI：15%~ 19%，I-2 = 91%），MSI发生率与年龄、性别、肿瘤部位和分期有关。在有种族数据的研究中，AA、西班牙裔和白人的MSI率分别为12%、12%和14%，差异无统计学意义。亚组分析的研究与种族信息表明MSI OR为0.78的AAs相比，高加索人。结论：CRC表现出的总体MSI频率为17%。AAs和高加索人之间的MSI频率差异并不明显，这表明其他因素导致了种族差异。不同研究之间MSI频率差异的方法学途径和生物学来源需要进一步研究。
PURPOSE: African Americans (AA) are at a higher risk of colorectal cancer (CRC) and some studies report a higher frequency of microsatellite instability (MSI) in this population while others report lower frequency compared to Caucasians.AIM: To determine and evaluate the association of race and clinical factors with MSI frequency through meta-analysis.METHODS: Twenty-two studies out of 15,105 (1997-2015) were evaluated after a search in different literature databases, using keywords "colorectal cancer, microsatellite instability, African Americans, Caucasians and Hispanics". We used random effect meta-analysis to calculate the MSI frequency in all studies as well as in African American and Caucasian samples. Meta-regression analysis was used to assess the univariate effect of race, gender, age, tumor location and stage on MSI frequency.RESULTS: The overall MSI frequency among CRCs was 17% (95% CI: 15%-19%, I-2 = 91%). In studies with available race data, The MSI rate among AAs, Hispanics and Caucasians were 12%, 12% and 14% respectively and was not significantly different. Sub-group analysis of studies with racial information indicates MSI OR of 0.78 for AAs compared to Caucasians.CONCLUSION: CRCs demonstrate an overall MSI frequency of 17%. MSI frequency differences between AAs and Caucasians were not pronounced, suggesting that other factors contribute to the racial disparity. The methodological approaches and biological sources of the variation seen in MSI frequency between different studies need to be further investigated.